Clinics in Chest Medicine, Volume 42, Issue 1: Sex Differences in Pulmonary Hypertension

Elsevier, Clinics in Chest Medicine, Volume 42, Issue 1, March 2021, Pages 217-228
Authors: 
Hannah Morris, Nina Denver, Rosemary Gaw, Hicham Labazi, Kirsty Mair, and Margaret R. MacLean

Pulmonary arterial hypertension (PAH) occurs in women more than men whereas survival in men is worse than in women. In recent years, much research has been carried out to understand these sex differences in PAH. This article discusses clinical and preclinical studies that have investigated the influences of sex, serotonin, obesity, estrogen, estrogen synthesis, and estrogen metabolism on bone morphogenetic protein receptor type II signaling, the pulmonary circulation and right ventricle in both heritable and idiopathic pulmonary hypertension.