Elsevier,
Energy and AI, Volume 5, September 2021
This article supports SDGs 7 and 9 by introducing interpretable artificial intelligence (AI) tools, especially proxy models based on artificial neural networks, efficient variable analysis and optimal value prediction of membrane electrode components in proton exchange membrane fuel cells, thereby improving their performance and reducing computational costs.
Redox Biology, Volume 45, September 2021
Niemann-Pick type C (NPC) disease, a lysosomal storage disorder caused by defective NPC1/NPC2 function, results in the accumulation of cholesterol and glycosphingolipids in lysosomes of affected organs, such as liver and brain. Moreover, increase of mitochondrial cholesterol (mchol) content and impaired mitochondrial function and GSH depletion contribute to NPC disease. However, the underlying mechanism of mchol accumulation in NPC disease remains unknown. As STARD1 is crucial in intramitochondrial cholesterol trafficking and acid ceramidase (ACDase) has been shown to regulate STARD1, we explored the functional relationship between ACDase and STARD1 in NPC disease.
Free Radical Biology and Medicine, Volume 173, September 2021
There is an urgent need to endorse a protective therapy for ALS patients. Possible treatments might be based on the underlying molecular pathophysiology. Some of the ALS dysregulated routes could be targeted by a single hit in NRF2. NRF2 emerged as a druggable target in preclinical and clinical trials for ALS.
Elsevier,
Environmental and Sustainability Indicators, Volume 11, September 2021
Scientists and governments of South Asian countries can work together more efficiently in the future, not just to react to the urban socio-economic and environmental problems of today, but work with superior foresight today to make strong decisions for tomorrow.
