Elsevier,
Australian Critical Care, Volume 37, July 2024
Although Indigenous Australians critically ill with sepsis have similar short and long-term mortality rates, they present to hospital, die in-hospital, and die post-discharge significantly younger. Unique cohort characteristics may explain these outcomes, and assist clinicians, researchers and policy-makers in targeting interventions to these characteristics to best reduce the burden of sepsis in this cohort and improve their healthcare outcomes.
Elsevier,
Journal of Anthropological Archaeology, Volume 74, June 2024
This archaeological anthropology paper discusses women's profound contributions to Arctic society. It looks at how needles are, and were, important women’s tools in the Iamal region of Siberia. How women’s sewing skills are crucial for the well-being of Arctic. families. How they form part of the women's cultural identities.
Elsevier,
Australian and New Zealand Journal of Public Health, Volume 48, June 2024
Māori and Pacific people want to take charge of their heart health but face challenges. Participants described important obligations to family, community and tikanga (the culturally correct way of doing things). Participants described times when health care undermined existing responsibilities, their dignity and/or their mana, and they felt excluded from treatment as a result.
Elsevier,
Journal of Nutrition, Volume 154, June 2024
The purpose of this scoping review was to determine the extent to which accessibility and acceptability of federal food assistance programs in the United States have been evaluated among indigenous peoples and to summarize what is currently known. Overall, it was found that little attention has been paid to the accessibility and acceptability of federal food assistance programs among indigenous peoples and more research is needed to understand and improve the participation experiences and health trajectories of these priority populations.
Elsevier,
Brain Research, Volume 1832, June 2024
Recent research on Alzheimer's disease (AD) suggests that microglia, immune cells in the brain, may play a beneficial role in early disease stages but become harmful in later stages due to various spatial, temporal, and transcriptional factors. Understanding the phenotypic heterogeneity and multiple states of microglia could lead to advancements in personalized medicine and improved treatment outcomes for AD patients.
Elsevier,
Mechanisms of Ageing and Development, Volume 219, June 2024
This study identified key biochemical pathways and protein changes in the Alzheimer's disease (AD) human hippocampus, revealing increased expression of proteins VGF, GFAP, HSPB1, and APP, with UBC being most centrally involved, and highlighted the roles of four hub proteins (CD44, APP, ITGB2, APOE) linked to amyloid plaques and two (RPL24, RPS23) to neurofibrillary tangles, along with the impact of modified proteins on immune activation and synaptic disruption, uncovering potential therapeutic targets involving specific proteins, microRNAs, and transcription factors.
Elsevier,
Brain Research Bulletin, Volume 212, 15 June 2024
This study reveals that Dl-3-n-butylphthalide (NBP) improves learning deficits and reduces Aβ plaque deposition in Alzheimer's disease (AD) transgenic mice by enhancing microglial activation and phagocytosis of Aβ plaques. The therapeutic effects of NBP are linked to the AGE-RAGE signaling pathway, demonstrating its potential in alleviating cognitive impairment and neuroinflammation in AD.
Elsevier,
IBRO Neuroscience Reports, Volume 16, June 2024
This article summarizes current biomarkers, available treatments, and future therapeutic approaches for Alzheimer's disease, discussing drug targets like Amyloid β, Tau Protein, and various other mechanisms. Additionally, it highlights the historical use of Estradiol, outcomes of trials with antioxidants and omega-3 fatty acids, and ongoing clinical trials, providing a comprehensive overview of the evolving landscape in AD research and treatment.
