Clinics in Chest Medicine, Volume 42, March 2021
Pulmonary arterial hypertension (PAH) occurs in women more than men whereas survival in men is worse than in women. In recent years, much research has been carried out to understand these sex differences in PAH. This article discusses clinical and preclinical studies that have investigated the influences of sex, serotonin, obesity, estrogen, estrogen synthesis, and estrogen metabolism on bone morphogenetic protein receptor type II signaling, the pulmonary circulation and right ventricle in both heritable and idiopathic pulmonary hypertension.
Sustainable Cities and Society, Volume 66, March 2021
The climate emergency and population growth are challenging water security and sustainable urban design in cities worldwide. Sustainable urban development is crucial to minimise pressures on the natural environment and on existing urban infrastructure systems, including water, energy, and land. These pressures are particularly evident in London, which is considered highly vulnerable to water shortages and floods and where there has been a historical shortage of housing. However, the impacts of urban growth on environmental management and protection are complex and difficult to evaluate.
