Articles

Elsevier,

Sustainable Cities and Society, Volume 27, 1 November 2016

Water reuse networks have been emerging globally for the last 50 years. This article reviews the economic, social and environmental issues related to implementing water reuse networks in cities. This is reflecting the fact that globally many cities are categorised as water scarce areas, where there is growing imbalance between water demand and availability. In this sense, there is a need for sustainable water supply solutions in the imminent future to provide and maintain service reliability, particularly in the face of climate change.

Elsevier,

Sustainable Cities and Society, Volume 27, 1 November 2016

Increases in water treatment technology have made water recycling a viable engineering solution to water supply limitations. In spite of this, such water recycling schemes have often been halted by lack of public acceptance. Previous studies have captured the public's attitudes regarding planned reuse schemes, but here we focus on unplanned reuse (i.e. de facto reuse), present in many cities across the U.S.

Elsevier,

Sustainable Cities and Society, Volume 27, 1 November 2016

Shortages of freshwater have become a serious issue in many regions around the world, partly due to rapid urbanisation and climate change. Sustainable city development should consider minimising water use by people living in cities and urban areas. The purpose of this paper is to improve our understanding of water-use behaviour and to reliably predict water use. We collected appropriate data of daily water use, meteorological parameters, and socioeconomic factors for the City of Brossard in Quebec, Canada, and analysed these data using multiple regression techniques.

Elsevier,

Sustainable Cities and Society, Volume 27, 1 November 2016

The study of resilience in the face of large physical and climatic change has emerged as an important area of research. But while the physical variables under study are easily identified, the notion of resilience itself remains nebulous. In recent years, it has been taken to mean both mitigation and adaptation, concepts that are often used in interchangeably or in conjunction (sometimes hyphenated as “adaptation-mitigation”).

Elsevier,

Sustainable Cities and Society, Volume 27, 1 November 2016

Water harvesting is an ancient practice that has been used, mainly in dry environments, to increase efficiency of water collection and use by directing water from a large natural watershed or man-made collection surface into a small basin where the water can be stored in underground reservoirs or to be used directly for irrigation or domestic uses. In modern era water harvesting has been neglected, particularly at the developed countries, due to the technological achievements in the fields of water production and transport.

Elsevier,

Sustainable Cities and Society, Volume 27, 1 November 2016

Combined Sewer Overflow (CSO) infrastructure are conventionally designed based on historical climate data. Yet, variability in rainfall intensities and patterns caused by climate change have a significant impact on the performance of an urban drainage system. Although rainwater harvesting (RWH) is a potential solution to manage stormwater in urban areas, its benefits in mitigating the climate change impacts on combined sewer networks have not been assessed yet.

The complexes of the mitochondrial respiratory chain.
Elsevier,

Mitochondrion, Volume 31, 1 November 2016

Mitochondrial respiratory chain dysfunction causes a variety of life-threatening diseases affecting about 1 in 4300 adults. These diseases are genetically heterogeneous, but have the same outcome; reduced activity of mitochondrial respiratory chain complexes causing decreased ATP production and potentially toxic accumulation of metabolites. Severity and tissue specificity of these effects varies between patients by unknown mechanisms and treatment options are limited. So far most research has focused on the complexes themselves, and the impact on overall cellular metabolism is largely unclear. To illustrate how computer modelling can be used to better understand the potential impact of these disorders and inspire new research directions and treatments, we simulated them using a computer model of human cardiomyocyte mitochondrial metabolism containing over 300 characterised reactions and transport steps with experimental parameters taken from the literature. Overall, simulations were consistent with patient symptoms, supporting their biological and medical significance. These simulations predicted: complex I deficiencies could be compensated using multiple pathways; complex II deficiencies had less metabolic flexibility due to impacting both the TCA cycle and the respiratory chain; and complex III and IV deficiencies caused greatest decreases in ATP production with metabolic consequences that parallel hypoxia. Our study demonstrates how results from computer models can be compared to a clinical phenotype and used as a tool for hypothesis generation for subsequent experimental testing. These simulations can enhance understanding of dysfunctional mitochondrial metabolism and suggest new avenues for research into treatment of mitochondrial disease and other areas of mitochondrial dysfunction.
Elsevier,

Press release November 1, 2016

Network organization Amsterdam Data Science (ADS) and Elsevier are collaborating together on several fronts, including research and development, joint promotion of Amsterdam as a data science center, and data science talent development. This partnership marks the first long-term collaboration agreement signed by ADS and is interetsed in advancing SDG 9 targets 5, B and C. A number of projects have already started. These are focused on improving data search and reproducibility of research that will ultimately result in higher quality research outcomes.

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