Elsevier, Trends in Food Science and Technology, Volume 90, August 2019
Background: Humanity's current use of resources is not in line with the goal of sustainable development. Climate change impact scenarios appear worryingly pessimistic. The agricultural and food production accounts for a particularly high share of the impact, and this also holds for consumption of food. Transforming food consumption plays a crucial role in tackling the challenges, and sensory consumer science can contribute to this.
Elsevier, World Development, Volume 120, August 2019
The number of countries with a national development plan has more than doubled, from about 62 in 2006 to 134 in 2018. More than 80 per cent of the global population now lives in a country with a national development plan of one form or another. This is a stunning recovery of a practice that had been discredited in the 1980s and 1990s as a relic of directed economies and state-led development. Several factors have fostered this re-emergence but from about 2015 the momentum for producing plans has accelerated, driven in part by a need to plan for the Sustainable Development Goals (SDGs).
Elsevier, Neuron, Volume 103, 7 August 2019
Traumatic brain injury (TBI) is one the most common human afflictions, contributing to long-term disability in survivors. Emerging data indicate that functional improvement or deterioration can occur years after TBI. In this regard, TBI is recognized as risk factor for late-life neurodegenerative disorders. TBI encompasses a heterogeneous disease process in which diverse injury subtypes and multiple molecular mechanisms overlap.
Elsevier, Agricultural and Forest Meteorology, Volume 274, 15 August 2019
Manual chamber-based measurements of CO2 (and H2O) fluxes are important for understanding ecosystem carbon metabolism. Small opaque chambers can be used to measure leaf, stem and soil respiration. Larger transparent chambers can be used to measure net ecosystem exchange of CO2, and small jars often serve this purpose for laboratory incubations of soil and plant material. We developed an Android application (app), called Flux Puppy, to facilitate chamber-based flux measurements in the field and laboratory.
Elsevier, Current Opinion in Green and Sustainable Chemistry, Volume 18, August 2019
In the last couple of years, deep eutectic solvents (DESs) have been raising a lot of attention mainly due to their versatility and their easy and speedy preparation without the need of further purification. Moreover, the vast array of very different compounds that can be selected for their preparation has led to the full tailoring of their relevant properties as solvents.
SLAS Discovery, Volume 24, 1 August 2019
High-throughput screening for drug discovery is increasingly utilizing cellular systems of high physiological relevance, such as patient primary cells and organoid cultures. We used 3D-cultured cystic fibrosis patient bronchial epithelial cells to screen for new small-molecule correctors of the disease-causing F508del mutation in CFTR. Impaired mucociliary clearance due to insufficient airway hydration is a hallmark of cystic fibrosis and we used a simple measure of surface liquid levels to quantify F508del CFTR correction in cultured bronchial epithelial cells. Two robust assay formats were configured and used to screen more than 100,000 compounds as mixtures or individual compounds in 96-well format. The corrector discovery success rate, as measured by the number of hits confirmed by an electrophysiology assay on patient primary bronchial epithelial cells, was superior to screens in cell lines expressing recombinant F508del CFTR. Several novel corrector scaffolds were discovered that when combined with the clinical corrector VX-809 delivered combination responses greater than double that of VX-809 alone. This work exemplifies the advantages of a disease-relevant readout and 3D-cultured patient primary cells for the discovery of new drug candidates.
Elsevier, Journal of Experimental Social Psychology, Volume 83, July 2019
Decades of research indicate that the traits we ascribe to people often depend on their race. Yet, the bulk of this research has not considered how racial stereotypes might also depend on other aspects of targets’ identities. To address this, researchers have begun to ask intersectional questions about racial stereotypes, such as whether they are applied in similar ways to men and women, or to children and adults. In the present studies, we examine whether men who are described as gay (vs. not) become de-racialized in the minds of perceivers. That is, we test whether gay (vs.
Elsevier, Journal of Healthcare Quality Research, Volume 34, July - August 2019
Objective: To report various components of health system responsiveness among poor internal migrants who availed the government health facilities in 13 Indian cities. Materials and methods: Cluster random sampling was used to select 50,806 migrant households, of which 14,263 households avail the government health facility in last six months. In addition, 5072 women, who sought antenatal care and 3946 women who had delivery in government health facility during last six months were also included.