, eClinicalMedicine, Volume 46, April 2022
Background: In autoimmune hepatitis (AIH), clinical practice and treatment guidelines frequently diverge as a reflection of disease heterogeneity and challenges in achieving standardised care. We sought to explore the utility of multiparametric (mp) MR in patients with AIH, and the impact of this technology on physicians’ decision making and intended patient management. Methods: 82 AIH patients, recruited from two sites between June and November 2019 as part of an observational cohort study, underwent non-contrast MRI alongside their standard clinical investigations.
, The Lancet Regional Health - Americas, Volume 8, April 2022
Background: Hepatitis C is a preventable and treatable disease that has been declared a public health problem. In 2012, the prevalence of HCV serum anti-bodies in the Mexican adult population aged 20 to 49 years was 0·30%. Methods: We randomly selected a probabilistic sub-sample of 12,389 adults (20+ years) from adults participating in the National Health and Nutrition Survey (ENSANUT) 2018 who provided a venous blood sample. Anti-HCV antibodies and HCV RNA were determined for this sub-sample.
, JHEP Reports, Volume 4, April 2022
Background & Aims: HBV infects over 257 million people worldwide and is associated with the development of hepatocellular carcinoma (HCC). Integration of HBV DNA into the host genome is likely a key driver of HCC oncogenesis. Here, we utilise targeted long-read sequencing to determine the structure of HBV DNA integrations as well as full isoform information of HBV mRNA with more accurate quantification than traditional next generation sequencing platforms. Methods: DNA and RNA were isolated from fresh frozen liver biopsies collected within the GS-US-174-0149 clinical trial.
The Lancet Public Health, 2022
Although older people have been recognised as a vulnerable group in humanitarian crises, they have not traditionally been considered a priority for humanitarian assistance.
Nanomaterials including engineered nanomaterials and nanoplastics emerge as new pollutants to the ecosystem. In particular, studies on the adverse effects of nanomaterials on the brain are limited. Various animal models offer opportunities to evaluate neurological effects of nanomaterials. We summarize recent studies and key findings on neurotoxicological effects of nanomaterials, focusing on zebrafish.
Journal of Integrative Agriculture, Volume 21, April 2022
Using agronomic experiment data from 62 studies between 1987 and 2021, we employ a meta-analysis to analyze the factors contributing to the heterogeneous effects of wastewater irrigation on crop yield.