The assembly of amyloidogenic peptides and proteins, such as the β-amyloid peptide, α-synuclein, huntingtin, tau, and islet amyloid polypeptide, into amyloid fibrils and oligomers is directly linked to amyloid diseases, such as Alzheimer's, Parkinson's, and Huntington's diseases, frontotemporal dementias, and type II diabetes. Although amyloid oligomers have emerged as especially important in amyloid diseases, high-resolution structures of the oligomers formed by full-length amyloidogenic peptides and proteins have remained elusive.
The diversification of tropical pastures with legumes (trees) for increased forage and animal productivity has been advocated. Nevertheless, effects on soil quality and belowground biodiversity, and the implications for sustainable intensification remain poorly documented, particularly when cattle grazing is included in the study. We evaluated the impact of forage system diversification with herbaceous and woody legumes on soil properties and soil macrofauna communities and their spatial heterogeneity in a three-year-old field trial in Cauca Valley, Colombia.
Neuropathic pain (NeuP) arises due to injury of the somatosensory nervous system and is both common and disabling, rendering an urgent need for non-addictive, effective new therapies. Given the high evolutionary conservation of pain, investigative approaches from Drosophila mutagenesis to human Mendelian genetics have aided our understanding of the maladaptive plasticity underlying NeuP. Successes include the identification of ion channel variants causing hyper-excitability and the importance of neuro-immune signaling.
Megacities contain at least 10 million people whose wellbeing largely depends on ecosystem services provided by remote natural areas. What is, however, most often disregarded is that nature conservation in the city can also contribute to human wellbeing benefits. The most common mind set separates cities from the rest of nature, as if they were not special kinds of natural habitats.
Sub-Saharan Africa needs to produce more food, feed, and fiber to support its growing population and intensification of smallholder agriculture is a crucial component of any strategy towards this goal. Sustainable Intensification (SI) acknowledges that enhanced productivity needs to go hand in hand with the maintenance of other ecosystem services and enhanced resilience to shocks. A very diverse group of smallholders dominate SSA agriculture, with large heterogeneity in socio-technical conditions, famer typologies, production objectives, and the biophysical environment.
