, Medical Image Analysis, Volume 67, January 2021
The enormous social and economic cost of Alzheimer's disease (AD) has driven a number of neuroimaging investigations for early detection and diagnosis. Towards this end, various computational approaches have been applied to longitudinal imaging data in subjects with Mild Cognitive Impairment (MCI), as serial brain imaging could increase sensitivity for detecting changes from baseline, and potentially serve as a diagnostic biomarker for AD. However, current state-of-the-art brain imaging diagnostic methods have limited utility in clinical practice due to the lack of robust predictive power.
, Biomedical Signal Processing and Control, Volume 57, March 2020
Clinical assessment of speech abnormalities in Cerebellar Ataxia (CA) is subjective and prone to intra- and inter-clinician inconsistencies. This paper presents an automated objective method based on a single syllable repetition task to detect and quantify speech-timing anomalies in ataxic speech. Such a technique is non-invasive, reliable, fast, cost-effective and can be used in the comfort of home without any professional assistance.