, eClinicalMedicine, Volume 46, April 2022
Background: In autoimmune hepatitis (AIH), clinical practice and treatment guidelines frequently diverge as a reflection of disease heterogeneity and challenges in achieving standardised care. We sought to explore the utility of multiparametric (mp) MR in patients with AIH, and the impact of this technology on physicians’ decision making and intended patient management. Methods: 82 AIH patients, recruited from two sites between June and November 2019 as part of an observational cohort study, underwent non-contrast MRI alongside their standard clinical investigations.
, Biomedical Signal Processing and Control, Volume 71, January 2022
A cerebrovascular accident or stroke is the second commonest cause of death in the world. If it is not fatal, it can result in paralysis, sensory impairment and significant disability. Rehabilitation plays an important role to help survivors relearn lost skills and assist them to regain independence and thus ameliorate their quality of life. With the development of technology, researchers have come up with new solutions to assist clinicians in monitoring and assessing their patients; as well as making physiotherapy available to all.
, Journal of Sexual Medicine, Volume 18, April 2021
Background: Female genital mutilation (FGM) can leave a lasting mark on the lives and minds of those affected. Aim: To assess the consequences of FGM on women's sexual function in women who have undergone FGM compared to women who have not undergone FGM. Methods: A systematic review and meta-analysis were conducted from 3 databases; inclusion and exclusion criterions were determined. Studies included adult women having undergone FGM and presenting sexual disorders assessed by the Female Sexual Function Index (FSFI). Results: Of 129 studies, 5 that met the criteria were selected.
, Mechanisms of Ageing and Development, Volume 190, September 2020
Diagnosis of Alzheimer's disease (AD) is often difficult because of distinct and subjective clinical features, especially in the early stage. FOXO3a protein present in the cognitive centre of brain in inferior temporal region and parahippocampus. FOXO3a can be a potential novel target against AD. AD, Mild Cognitive impairment (MCI) and Geriatric Control (GC) were recruited after diagnosis by clinical assessment, MRI, TauPET and FDG-PET. We have quantified serum FOXO3a by surface plasmon resonance (SPR) and compare with TauPET between of AD, MCI patients and GC.
, Journal of Sexual Medicine, Volume 17, April 2020
Background: There is a general lack of recommendations for and basic information tailored at sexologists and other health-care professionals for when they encounter trans people in their practice. Aim: We present to clinicians an up-to-date overview of clinical consensus statements on trans health care with attention for sexual function and satisfaction. Methods: The task force consisted of 7 clinicians experienced in trans health care, selected among European Society for Sexual Medicine (ESSM) scientific committee.
, Biomedical Signal Processing and Control, Volume 57, March 2020
Clinical assessment of speech abnormalities in Cerebellar Ataxia (CA) is subjective and prone to intra- and inter-clinician inconsistencies. This paper presents an automated objective method based on a single syllable repetition task to detect and quantify speech-timing anomalies in ataxic speech. Such a technique is non-invasive, reliable, fast, cost-effective and can be used in the comfort of home without any professional assistance.
, Clinical Nutrition ESPEN, Volume 24, April 2018
Background: Older adults are at increased risk of malnutrition compared to their younger counterparts. Malnutrition screening should be conducted using a valid malnutrition screening tool. An aim of the Healthy Diet for a Healthy Life (HDHL) Joint Programming Initiative (JPI) ‘Malnutrition in the Elderly Knowledge Hub’ (MaNuEL) was to review the reported validity of existing malnutrition screening tools used in older adults.
, Maturitas, Volume 107, January 2018
Objectives Gender identity disorder is defined as a strong and persistent cross-gender identification that is associated with a remarkable uneasiness of living in an incongruent gender (gender dysphoria). We performed a retrospective study on the hormonal and metabolic effects of cross-sex hormone therapy (CSHT) in a small cohort of transgender patients. Study design Retrospective study. Mean outcome measures Hormonal and biochemical parameters at baseline (i.e.
Background Established in 2000, Millennium Development Goal 4 (MDG4) catalysed extraordinary political, financial, and social commitments to reduce under-5 mortality by two-thirds between 1990 and 2015. At the country level, the pace of progress in improving child survival has varied markedly, highlighting a crucial need to further examine potential drivers of accelerated or slowed decreases in child mortality.
, The Lancet, Volume 385, 18 April 2015
Health systems have a crucial role in a multisector response to violence against women. Some countries have guidelines or protocols articulating this role and health-care workers are trained in some settings, but generally system development and implementation have been slow to progress. Substantial system and behavioural barriers exist, especially in low-income and middle-income countries.