The Lancet Planetary Health, Volume 5, December 2021
An Article in support of SDGs 3 and 13, highlighting widespread climate anxiety and dissatisfaction with government responses to climate change among chidren globally, with government inaction on climate change described as a human rights failure that could have considerable, long-lasting, and incremental negative implications for the mental health of children and young people.
, One Earth, Volume 4, 17 December 2021
Behavioral science approaches to promoting sustainable action have mainly focused on cognitive processes, whereas the role of emotions has received comparably little attention. However, emotions have a great but currently not fully exploited potential to contribute to a sustainable behavior change. In this perspective, we summarize recent research emphasizing the central and indispensable role of emotion in human thinking and judgment.
, The Lancet Respiratory Medicine, Volume 9, November 2021
Background: The impact of COVID-19 on physical and mental health and employment after hospitalisation with acute disease is not well understood. The aim of this study was to determine the effects of COVID-19-related hospitalisation on health and employment, to identify factors associated with recovery, and to describe recovery phenotypes.
, Behavioural Brain Research, Volume 414, 24 September 2021
Rho-associated coiled-coil kinase (ROCK), a serine/threonine kinase regulated by the small GTPase RhoA, is involved in regulating cell migration, proliferation, and survival. Numerous studies have shown that the RhoA/ROCK signaling pathway can promote Alzheimer's disease (AD) occurrence. ROCK activation increases β-secretase activity and promotes amyloid-beta (Aβ) production; moreover, Aβ further activates ROCK. This is suggestive of a possible positive feedback role for Aβ and ROCK. Moreover, ROCK activation promotes the formation of neurofibrillary tangles and abnormal synaptic contraction.
The Lancet Child and Adolescent Health, Volume 5, July 2021
This study supports SDG 3 and 10 by highlighting an overrepresentation of Black children and adolescents in involuntary psychiatric hospitalisations, which may establish potentially lifelong negative mental health treatment trajectories and contribute to cycles of health inequality that persist in later life.
, The Lancet Psychiatry, Volume 8, June 2021
Background: The prevalence of head injury is estimated to be as high as 55% in women in prison and might be a risk factor for violent offending, but evidence is equivocal. The extent of persisting disability is unknown, making decisions about service needs difficult. The UN recognises vulnerabilities in women in prison, but does not include head injury. This study aimed to investigate relationships among head injury, comorbidities, disability, and offending in women in prison.
The Lancet Global Health, Volume 9, March 2021
This Viewpoint supports SDGs 3, 6, and 7 by discussing some of the reasons why many of the innovations and technologies for WASH (water, sanitation, and hygiene) and household air pollution developed in recent decades have not led to the expected improvements in health outcomes, and why many of these interventions have either been inconsistently adopted by low-income households, or not adopted at all.
, Frontiers in Neuroendocrinology, Volume 60, January 2021
Women represent ⅔ of the cases of Alzheimer's disease (AD). Current research has focused on differential risks to explain higher rates of AD in women. However, factors that reduce risk for AD, like cognitive/brain reserve, are less well explored. We asked: what is known about sex and gender differences in how reserve mitigates risk for AD?
, Journal of Steroid Biochemistry and Molecular Biology, Volume 205, January 2021
Background and Purpose: Altered cholesterol metabolism is associated with increased risk of neurodegeneration and in particular with the development of Alzheimer's disease (AD). Here, we investigate whether non-cholesterol sterols and oxysterols in the central nervous system are associated with (i) the presence of cerebral AD pathology, (ii) distinct aspects of AD pathology, i.e. amyloid pathology, neuronal injury, and tau pathology, and (iii) cognitive decline over time.
, EClinicalMedicine, Volume 28, November 2020
Background: The aim of this study is to use classification methods to predict future onset of Alzheimer's disease in cognitively normal subjects through automated linguistic analysis. Methods: To study linguistic performance as an early biomarker of AD, we performed predictive modeling of future diagnosis of AD from a cognitively normal baseline of Framingham Heart Study participants. The linguistic variables were derived from written responses to the cookie-theft picture-description task.