, Journal of Hepatology, Volume 76, February 2022
Background & aims: Recent experimental models and epidemiological studies suggest that specific environmental contaminants (ECs) contribute to the initiation and pathology of non-alcoholic fatty liver disease (NAFLD). However, the underlying mechanisms linking EC exposure with NAFLD remain poorly understood and there is no data on their impact on the human liver metabolome. Herein, we hypothesized that exposure to ECs, particularly perfluorinated alkyl substances (PFAS), impacts liver metabolism, specifically bile acid metabolism.
, The Lancet Planetary Health, Volume 6, January 2022
Background: Long-term exposure to ambient air pollution has been associated with premature mortality, but associations at concentrations lower than current annual limit values are uncertain. We analysed associations between low-level air pollution and mortality within the multicentre study Effects of Low-Level Air Pollution: A Study in Europe (ELAPSE).
, Biomedical Signal Processing and Control, Volume 71, January 2022
A cerebrovascular accident or stroke is the second commonest cause of death in the world. If it is not fatal, it can result in paralysis, sensory impairment and significant disability. Rehabilitation plays an important role to help survivors relearn lost skills and assist them to regain independence and thus ameliorate their quality of life. With the development of technology, researchers have come up with new solutions to assist clinicians in monitoring and assessing their patients; as well as making physiotherapy available to all.
, The Lancet Planetary Health, Volume 5, November 2021
Background: Unhealthy diets, the rise of non-communicable diseases, and the declining health of the planet are highly intertwined, where food production and consumption are major drivers of increases in greenhouse gas emissions, substantial land use, and adverse health such as cancer and mortality. To assess the potential co-benefits from shifting to more sustainable diets, we aimed to investigate the associations of dietary greenhouse gas emissions and land use with all-cause and cause-specific mortality and cancer incidence rates.
, The Lancet Respiratory Medicine, Volume 9, November 2021
Background: The impact of COVID-19 on physical and mental health and employment after hospitalisation with acute disease is not well understood. The aim of this study was to determine the effects of COVID-19-related hospitalisation on health and employment, to identify factors associated with recovery, and to describe recovery phenotypes.
, The Lancet Public Health, Volume 6, November 2021
Background: People with learning disabilities are at substantially increased risk of COVID-19 mortality, but evidence on risks of COVID-19 mortality for disabled people more generally is limited. We aimed to use population-level data to estimate the association between self-reported disability and death involving COVID-19 during the first two waves of the COVID-19 pandemic in England.
, The Lancet Global Health, Volume 9, August 2021
Background: The effects of the COVID-19 pandemic on mental health have been understudied among vulnerable populations, particularly in fragile and conflict-affected settings. We aimed to analyse how the pandemic is related to early changes in mental health and parenting stress among caregivers, many of whom are internally displaced persons (IDP), in a conflict-affected setting in Colombia. Methods: For this cohort study, we used longitudinal data from a psychosocial support programme in which 1376 caregivers were randomly assigned across four sequential cohorts.
, The Lancet Public Health, Volume 6, July 2021
Background: WHO has launched an initiative aiming to eliminate cervical cancer as a public health problem. Elimination is a long-term target that needs long-lasting commitment. To support local authorities in implementing human papillomavirus (HPV) vaccination, we provide regional and country-specific estimates of cervical cancer burden and the projected impact of HPV vaccination among today's young girls who could develop cervical cancer if not vaccinated.
The Lancet Diabetes and Endocrinology, Volume 9, July 2021
This article supports SGDs 3 and 10 by identifying ethnicity-specific body-mass index cutoffs for obesity based on type 2 diabetes risk-equivalence to the cutoff in White populations. The findings suggest ethnicity-specific body-mass index cutoffs are needed to optimise prevention and management of type 2 diabetes.
eClinicalMedicine, Volume 37, July 2021
This study supports SDGs 3 and 10 by investigating the role of genetic ancestry in ethnic disparities in type 2 diabetes, and interactions with socioeconomic deprivation. The effects of environmental risk factors were found to differ among ancestry groups, suggesting the need for group-specific interventions.