Graphical abstract showing the effect of estrogen-deficiency on a tooth
Emerging evidence indicates that postmenopausal women with periodontitis have aggravated inflammation and prolonged course, with the detailed mechanisms largely unknown. This study aimed to determine the pathogenic role of aberrant extracellular vesicles due to imbalanced-polarized macrophages and explore the therapeutic approach for periodontitis in postmenopausal individuals. Periodontitis in ovariectomized (OVX) mouse models were established to simulate the aggravated periodontitis in postmenopausal women.

Materials Today Advances, Volume 13, March 2022

In this review, the authors summarize the latest understanding on the detection, concentration, and evaluation of SARS-CoV-2 in wastewater.
Meat consumption has been increasing since the 1960s, but especially from the 1980s decade to today. Although meat means an important source of nutrients, it is also evident that a great consumption of this source of proteins has also a negative environmental impact. Livestock production does not only have a negative influence on GHG emissions, but also on the water footprint, water pollution, and water scarcity.
Objective imaging-based biomarker discovery for psychiatric conditions is critical for accurate diagnosis and treatment. Using a machine learning framework, this work investigated the utility of brain's functional network topology (complex network features) extracted from functional magnetic resonance imaging (fMRI) functional connectivity (FC) as viable biomarker of autism spectrum disorder (ASD). To this end, we utilized resting-state fMRI data from the publicly available ABIDE dataset consisting of 432 ASD patients and 556 matched healthy controls.
Within a time span of only a few months, the SARS-CoV-2 virus has managed to spread across the world. This virus can spread by close contact, which includes large droplet spray and inhalation of microscopic droplets, and by indirect contact via contaminated objects. While in most countries, supermarkets have remained open, due to the COVID-19 pandemic, authorities have ordered many other shops, restaurants, bars, music theaters and indoor sports centers to be closed.
Purpose: Radiation therapy interruption (RTI) worsens cancer outcomes. Our purpose was to benchmark and map RTI across a region in the United States with known cancer outcome disparities. Methods and Materials: All radiation therapy (RT) treatments at our academic center were cataloged. Major RTI was defined as ≥5 unplanned RT appointment cancellations. Univariate and multivariable logistic and linear regression analyses identified associated factors. Major RTI was mapped by patient residence.
Infectious diseases have proven to be remarkably resilient foes of human health and so the prevention and control of infectious diseases have been attracting the attention of all countries over the world. Vaccination is an effective way to prevent the spread of infectious diseases. However, vaccination is a long-standing social dilemmas due to the vaccine's risk by itself and the spread of infectious diseases in the population depends on not only the pathogen itself, but also the impact of social network structures.
Nanotechnology provides an emerging potent alternate mode of cancer therapy. Nanomaterials dispersion or solubility is of particular concern in utilising their full potential applications in biomedical fields. PEGylation of nanomaterials is considered to provide products with stealth properties, and physiological environment with no obvious adverse effects. The purpose of this work was to develop a sustainable one-step method for fabrication of hierarchical microspheres of PEGylated MoS 2 nanosheets using a stoichiometric ratio of Mo(VI) and thiourea.
Climate change refers to long-term shifts in weather conditions and patterns of extreme weather events. It may lead to changes in health threat to human beings, multiplying existing health problems. This review examines the scientific evidences on the impact of climate change on human infectious diseases. It identifies research progress and gaps on how human society may respond to, adapt to, and prepare for the related changes.