Early Detection

Screening with low-dose computed tomography of high-risk individuals with a smoking history reduces lung cancer mortality. Current screening guidelines and eligibility criteria can miss more than 50% of lung cancers, and in some geographic areas, such as East Asia, a large proportion of the missed lung cancers are in never-smokers. Although randomized trials revealed the benefits of screening for people who smoke, these trials generally excluded never-smokers. Thus, the feasibility and effectiveness of lung cancer screening of individuals who never smoked are uncertain.
Diabetic Retinopathy (DR) is one of the leading causes of preventable blindness in the working-age diabetic population in India and across the world. It may lead to permanent blindness if not detected in the early stages. The prevalence of DR among diabetics in India was 10% and 16.9% in 2014 and 2019, respectively. In 2019, the International Diabetes Federation estimated that Diabetic Mellitus will affect 101 million people in India in 2030; the largest number in any nation in the world.
Due to advances in the early detection of Alzheimer's disease (AD) biomarkers including beta-amyloid (Aβ), neuropsychological measures that are sensitive to concurrent, subtle changes in cognition are critically needed. Story recall tasks have shown sensitivity to early memory declines in persons with mild cognitive impairment (MCI) and early stage dementia, as well as in persons with autosomal dominantly inherited AD up to 10 years prior to a dementia diagnosis. However, the evidence is inconclusive regarding relationships between evidence of Aβ and story recall measures.