Energy Metabolism

Neuropathic pain (NeuP) arises due to injury of the somatosensory nervous system and is both common and disabling, rendering an urgent need for non-addictive, effective new therapies. Given the high evolutionary conservation of pain, investigative approaches from Drosophila mutagenesis to human Mendelian genetics have aided our understanding of the maladaptive plasticity underlying NeuP. Successes include the identification of ion channel variants causing hyper-excitability and the importance of neuro-immune signaling.
Interest about interactions between microplastics and organisms is on the rise. Accessing organisms’ responses to these chemically “inert” compounds plays an important role in determining their potential toxicity. Microplastics from the environment tend to accumulate and move through living organisms, inducing a variety of biological effects, such as disturbances in energy metabolism, oxidative balance, antioxidative capacity, DNA, immunological, neurological and histological damage.