Background: Individuals with COPD have increased sensitivity to traffic-related air pollution (TRAP) such as diesel exhaust (DE), but little is known about the acute effects of TRAP on exercise responses in COPD. Research Question: Does exposure before exercise to TRAP (DE titrated to 300 μg/m3 particulate matter
Elsevier, The Lancet, Volume 398, 30 October 2021
Elsevier, The Lancet, Volume 398, 31 July 2021
Approximately 1·5 billion people worldwide live with a physical, mental, sensory, or intellectual disability, about 80% of which are in low-income and middle-income countries. This Series paper provides a global overview of the prevalence, benefits, and promotion policies for physical activity for people living with disabilities (PLWD). PLWD are 16–62% less likely to meet physical activity guidelines and are at higher risk of serious health problems related to inactivity than people without disabilities.
Elsevier, The Lancet Public Health, Volume 6, June 2021
Elsevier, Physiology and Behavior, Volume 223, 1 September 2020
Swimming exercise improves cognitive and behavioral disorders in male NMRI mice with sporadic Alzheimer-like disease
Alzheimer's disease (AD) is associated with cognitive deficits and behavioral disorders such as anxiety and depression. Recent clinical and experimental studies have demonstrated that swimming exercise could be a potential therapy for cognitive and behavioral disorders. The prevalence of anxiety and depression is increasing among patients with AD; hence, further studies are needed to develop therapies for these behavioral abnormalities.
Elsevier, Metabolism: Clinical and Experimental, Volume 101, December 2019
Supervised lifestyle intervention for people with metabolic syndrome improves outcomes and reduces individual risk factors of metabolic syndrome: A systematic review and meta-analysis
Background: Metabolic syndrome is characterised by a clustering of metabolic risk factors including abdominal obesity, raised triglycerides, lowered HDL cholesterol, hypertension and impaired glucose tolerance. Multifaceted lifestyle interventions including diet and exercise are recommended as the first-line treatment for the metabolic syndrome. Objective: To investigate the effects of lifestyle interventions that include both diet interventions and supervised exercise on outcomes for people with metabolic syndrome. Methods: A systematic review and meta-regression was conducted.
Elsevier, Journal of Hepatology, Volume 70, May 2019
Association between physical activity and risk of hepatobiliary cancers: A multinational cohort study
Background & Aims: To date, evidence on the association between physical activity and risk of hepatobiliary cancers has been inconclusive. We examined this association in the European Prospective Investigation into Cancer and Nutrition cohort (EPIC). Methods: We identified 275 hepatocellular carcinoma (HCC) cases, 93 intrahepatic bile duct cancers (IHBCs), and 164 non-gallbladder extrahepatic bile duct cancers (NGBCs) among 467,336 EPIC participants (median follow-up 14.9 years).
Elsevier, Operations Research for Health Care, Volume 19, December 2018
Supporting healthy route choice for commuter cyclists: The trade-off between travel time and pollutant dose
Cyclists form the most vulnerable road user group in terms of injury from traffic accidents, as well as exposure to traffic-related air pollution. Ironically, commuter cyclists are often motivated by improvement in health and fitness. Cycleways away from traffic with lower concentrations of pollutants from motorised vehicles sometimes result in longer distances and hence require longer travel times, while alternative routes sharing the road with other traffic, sometimes with buses, might result in exposure to higher pollutant concentrations.
Elsevier, Neurobiology of Stress, Volume 9, November 2018
Exercise has been shown to reduce the risk of developing Mild Cognitive Impairment and Alzheimer's disease as well as to improve cognition in healthy and cognitively impaired individuals. However, the mechanisms of these benefits are not well understood. The stress hypothesis suggests that the cognitive benefits attributed to exercise may partially be mediated by changes in the cortisol secretion pattern.
Elsevier, Neurobiology of Stress, Volume 8, February 2018
Physical activity and stress are both environmental modifiers of Alzheimer's disease (AD) risk. Animal studies of physical activity in AD models have largely reported positive results, however benefits are not always observed in either cognitive or pathological outcomes and inconsistencies among findings remain. Studies using forced exercise may increase stress and mitigate some of the benefit of physical activity in AD models, while voluntary exercise regimens may not achieve optimal intensity to provide robust benefit.