Coenzyme Q10 (CoQ10) deficiency syndrome is a rare disease included in the family of mitochondrial diseases, which is a heterogeneous group of genetic disorders characterized by defective energy production. CoQ10 biosynthesis in humans requires at least 11 gene products acting in a multiprotein complex within mitochondria. The high-throughput screening (HTS) method based on the stabilization of the CoQ biosynthesis complex (Q-synthome) produced by the COQ8 gene overexpression is proven here to be a successful method for identifying new molecules from natural extracts that are able to bypass the CoQ6 deficiency in yeast mutant cells. The main features of the new approach are the combination of two yeast targets defective in genes with different functions on CoQ6 biosynthesis to secure the versatility of the molecule identified, the use of glycerol as a nonfermentable carbon source providing a wide growth window, and the stringent conditions required to mark an extract as positive. The application of this pilot approach to a representative subset of 1200 samples of the Library of Natural Products of Fundación MEDINA resulted in the finding of nine positive extracts. The fractionation of three of the nine extracts allowed the identification of five molecules; two of them are present in molecule databases of natural extracts and three are nondescribed molecules. The use of this screening method opens the possibility of discovering molecules with CoQ10-bypassing action useful as therapeutic agents to fight against mitochondrial diseases in human patients.
Elsevier,
Adolescent Addiction (Second Edition), Epidemiology, Assessment, and Treatment, Practical Resources for the Mental Health Professional, 2020, Pages 215-240
This chapter addresses Goal 3 by discussing smartphone addiction in adolescents.
This chapter supports SDGs 3 and 16 by describing disaster management in the international context and introduces the community of international disaster management stakeholders (which includes governmental agencies, international organizations, nongovernmental organizations, and financial institutions) that support the preparedness for, mitigation of, response to, and recovery from disaster events.
Background: Pregnancy is characterized with several physical and mental changes in women. These changes cause mental health problems in pregnant women and especially in nulliparous women.
Environmentalism and sustainability are two buzzwords that have come to represent an awakening of the people's collective conscience over the last two decades or so.
Elsevier,
Evidence-informed Approaches for Managing Dementia Transitions: Riding the Waves, Volume , 4 February 2020
This book chapter advances SDGs 3 and 17 by focusing on the need to establish equilibrium and well-being and is organized around eight themes using the acronym R-E-A-D-J-U-S-T. The chapter ties these themes with a call for more research and reinforcement for inclusion of the voices of people with dementia.
Elsevier,
Evidence-informed Approaches for Managing Dementia Transitions: Riding the Waves, Volume , 4 February 2020
This book chapter advances SDGs 3 and 17 by introducing aspects of the lived experience, management, and epidemiology of dementia and some of the significant transitions that people with the disease and their caregivers frequently encounter.
Elsevier,
Evidence-informed Approaches for Managing Dementia Transitions: Riding the Waves, Volume , 4 February 2020
This book chapter advances SDGs 3 and 17 by describing the prevalence of dementia in hospitalized patients, reasons for hospitalizations, and risks to older people with dementia in hospitals. Strategies for optimizing outcomes and models of care that are designed to improve care of persons with dementia and their care partners are described to assist healthcare team members working with this unique population.
Elsevier,
An Introduction to Interdisciplinary Toxicology, From Molecules to Man, 2020, Pages 353-361
The water crisis in Flint, Michigan, a human made disaster of dire proportions, resulted in bacterial and lead contamination of predominantly African American and low-income residents. SDG 6 promotes to ensure availability and sustainable management of water and sanitation for all.
Elsevier,
An Introduction to Interdisciplinary Toxicology, From Molecules to Man, 2020, Pages 341-352
This chapter examines the contaminated community phenomenon by situating it within social science scholarship on hazards and disasters. The goal of SDG target 3.9 is to substantially reduce the number of deaths and illnesses from hazardous chemicals and air, water and soil pollution and contamination.
