Here, Nestler and Lüscher link addiction circuits to epigenetic mechanisms that are engaged by drug exposure or reflect life experience.
Threat processing is central to understanding debilitating fear- and trauma-related disorders such as posttraumatic stress disorder (PTSD).
Perinatal depression (PND) is a heterogeneous disorder with differences in timing of onset of depression, which influences symptomology, severity, and treatment efficacy.
Background: Genetic diversity is a characteristic trait of the hepatitis B virus (HBV) and has been associated with different clinical outcomes.
Cystic fibrosis is a genetic disease affecting more than 70,000 people worldwide. Caused by a mutation in the CFTR gene, cystic fibrosis can result in difficulty breathing, widespread bacterial infections, edema, malnutrition, pancreatitis, and death. Current drug-based treatments struggle to reach the site of action due to the thick mucus, and only manage symptoms such as blocked airways, lung infections, and limited ability to digest food. Nanotechnology opens up possibilities for improved treatment strategies by focusing on drug penetration through the mucus lining, eliminating resulting bacterial infections, and targeting the underlying genetic cause of the disease. In this review, we present recent nanoparticle developments for cystic fibrosis, challenges in nanomedicine therapeutics, and future research directions in gene editing and nonviral vectors for gene delivery.
More than 30 sterols/oxysterols/sterol-acids analysed in human CSF. 7α,25-Dihydroxy-3-oxocholest-4-en-26-oate reduced in AD patient-group. 7α,25-Dihydroxy-3-oxocholest-4-en-26-oate – an intermediate in bile acid synthesis. Bile acid synthesis linked to AD.
Dementia can disturb the circadian rhythm more than in normal ageing people. And their biological clock is often not enough stimulated by light.
