In vivo triple transgenic AD mouse model brains and retinas showed hypoxic vessels expressing hypoxyprobe and HIF-1α. In in vitro OGD-treated endothelial cells, HIF-1α upregulated NADPH oxidase (NOX) (i.e., Nox2, Nox4). NLRP1 protein was promoted by OGD, and such effect was blocked by downregulation of Nox4 and HIF-1α. Hypoxic endothelial cells of AD brains and retinas markedly expressed NLRP1, ASC, caspase-1, and interleukin-1β (IL-1β). Chronic hypoxia in microvascular endothelial cells leads to HIF-1α-NLRP1 circuit in AD.
This study observes that oxidative dame in Alzheimer's Diseases is a pathogenic mechanism at the cell-tissue level.
World Hepatitis Day takes place every year on 28 July to raise awareness of the global burden of viral hepatitis. To highlight this important disease, Elsevier is proud to host this special collection of book chapters and journal articles which are freely available to download.
This paper reviews the unique perspective that Indigenous People have on the HIV/AIDS epidemic, and the interactions between Indigenous Identities and HIV. The authors call for a human rights based approach to ending the HIV epidemic among Indigenous Peoples.
This article aligns with the SDG goal 3 of Good health and wellbeing by creating a nomogram useful for clinical decision making that shows good performance in predicting the 1-year survival rate in patients with HBV-related HCC.
This Article supports SDG 3 by analysing peripartum antiviral prophylaxis for hepatitis B in 110 countries, finding that it could be beneficial in averting both neonatal hepatitis B infections and DALYS, and that it might be cost-effective depending on how it is implemented and the associated diagnostic costs.
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Brain Responses to Auditory Mismatch and Novelty Detection, First Edition, 2023, pp 271-314
This chapter advances the UN SDG goals 3 and 17 understanding whether decreasing network connectivity in aging is independent of changes across cognitive networks or is accelerated by mild cognitive impairment and AD.
This Article supports Sustainable Development Goal 3 by assessing the impact of physical activity and sleep on 10-year cognitive decline in older people. They showed that the cognitive benefits associated with increased activity were not enough to ameliorate decline associated with short sleep.
This article reviews collaborative mindset required to tackle global problem of AD.
This content ties into the SDG goal by exploring music and how it can best be used to help decrease agitation in patients with Alzheimer's and related dementias
