Climate change will expose mammals to an array of stressors, some new, and some with increased frequency and severity. Those stressors influence endocrine and metabolic function, with potential consequences for the survival and persistence of mammalian species. Here, we review the similar consequences of climate change on the physiological function of terrestrial mammals, including direct effects of increasing air temperatures and reduced water availability, as well as the indirect effect of reduced or unpredictable food supply.
RNA binding proteins are critical to the maintenance of the transcriptome via controlled regulation of RNA processing and transport. Alterations of these proteins impact multiple steps of the RNA life cycle resulting in various molecular phenotypes such as aberrant RNA splicing, transport, and stability. Disruption of RNA binding proteins and widespread RNA processing defects are increasingly recognized as critical determinants of neurological diseases.
