Management of menstruation, pregnancy prevention, and mitigation of gynecologic-related pathology in the space environment with or without the use of hormonal modalities requires thorough counseling and complex decision-making.
This review discusses established transgender individuals on hormones who have reached their desired post-pubertal phenotype. Current guidelines have not clearly integrated specific considerations for the older population. This review focuses on changes in physiology with age, recommended maintenance therapy and safety evaluation to mitigate the risks of hormone therapy with a focus on the older population.
