Clinical and social factors associated with involuntary psychiatric hospitalisation in children and adolescents: a systematic review, meta-analysis, and narrative synthesis
The Lancet Child and Adolescent Health, Volume 5, July 2021
This study supports SDG 3 and 10 by highlighting an overrepresentation of Black children and adolescents in involuntary psychiatric hospitalisations, which may establish potentially lifelong negative mental health treatment trajectories and contribute to cycles of health inequality that persist in later life.
Background: The pathological changes in Alzheimer's Disease (AD) and other neurodegenerative disorders begin decades prior to their clinical expression. However, the clinical diagnosis of neurodegenerative dementias is not straightforward. Lactoferrin is an iron-binding, antimicrobial glycoprotein with a plethora of functions, including acting as an important immune modulator and by having a bacteriocidic effect. Two previous studies indicated that salivary lactoferrin could differentiate between neurodegenerative dementias.
Elsevier, Journal of Steroid Biochemistry and Molecular Biology, Volume 205, January 2021
Cholesterol metabolites and plant sterols in cerebrospinal fluid are associated with Alzheimer's cerebral pathology and clinical disease progression
Background and Purpose: Altered cholesterol metabolism is associated with increased risk of neurodegeneration and in particular with the development of Alzheimer's disease (AD). Here, we investigate whether non-cholesterol sterols and oxysterols in the central nervous system are associated with (i) the presence of cerebral AD pathology, (ii) distinct aspects of AD pathology, i.e. amyloid pathology, neuronal injury, and tau pathology, and (iii) cognitive decline over time.
Elsevier, Biomedical Signal Processing and Control, Volume 62, September 2020
Comparison of 1.5 T and 3 T MRI hippocampus texture features in the assessment of Alzheimer's disease
Objective: Many studies evaluated how the Magnetic Resonance Imaging (MRI) field strength affects the effectiveness to detect neurodegenerative changes of Alzheimer's disease (AD), derived from atrophy or thickness. To the best of our knowledge, no study evaluated before how tissue texture changes are affected. In this research, hippocampus texture features extracted from 1.5 T and 3 T MRI are evaluated how are affected by the magnetic field strength.
Elsevier, EBioMedicine, Volume 59, September 2020
CHRFAM7A: A human specific fusion gene, accounts for the translational gap for cholinergic strategies in Alzheimer's disease
Background: Cholinergic neuronal loss is one of the hallmarks of AD related neurodegeneration; however, preclinical promise of α7 nAChR drugs failed to translate into humans. CHRFAM7A, a uniquely human fusion gene, is a negative regulator of α7 nAChR and was unaccounted for in preclinical models. Methods: Molecular methods: Function of CHRFAM7A alleles was studied in vitro in two disease relevant phenotypic readouts: electrophysiology and Aβ uptake. Genome edited human induced pluripotent stem cells (iPSC) were used as a model system with the human context.
Elsevier, Cortex, Volume 115, June 2019
Background: Memory for music has attracted much recent interest in Alzheimer's disease but the underlying brain mechanisms have not been defined in patients directly. Here we addressed this issue in an Alzheimer's disease cohort using activation fMRI of two core musical memory systems. Methods: We studied 34 patients with younger onset Alzheimer's disease led either by episodic memory decline (typical Alzheimer's disease)or by visuospatial impairment (posterior cortical atrophy)in relation to 19 age-matched healthy individuals.