, Current Opinion in Chemical Biology, Volume 64, October 2021
The assembly of amyloidogenic peptides and proteins, such as the β-amyloid peptide, α-synuclein, huntingtin, tau, and islet amyloid polypeptide, into amyloid fibrils and oligomers is directly linked to amyloid diseases, such as Alzheimer's, Parkinson's, and Huntington's diseases, frontotemporal dementias, and type II diabetes. Although amyloid oligomers have emerged as especially important in amyloid diseases, high-resolution structures of the oligomers formed by full-length amyloidogenic peptides and proteins have remained elusive.
, The Lancet Planetary Health, Volume 5, June 2021
Background: Stunting rates in children younger than 5 years are among the most important health indicators globally. At the national level, malnutrition accounts for about 40% of under-5 deaths in Ghana. Disease risk mapping provides opportunities for disease surveillance and targeted interventions. We aimed to estimate and map under-5 stunting prevalence in Ghana, with the goal of identifying communities at higher risk where interventions and further research can be targeted. Methods: For this modelling study, we used data from the 2014 Ghana Demographic and Health Survey.
, Ageing Research Reviews, Volume 58, March 2020
Chronological age is a commonly-used time metric, but there may be more relevant time measures in older adulthood. This paper reviews change point modeling, a type of analysis increasingly common in cognitive aging research but with limited application in applied research. Here, we propose a new application of such models for cognitive training studies.
, Ecological Modelling, Volume 391, 10 January 2019
Using a consumption-based Multi-Regional Input-Output (MRIO) model, we investigate the distinctive characteristics, self-efficiency or external dependency, of energy demand's water footprint in China's two biggest and fastest developing megalopolises. We find that energy demand water footprint in the Jing-Jin-Ji and the Yangtze Delta amounted to 2.41 and 9.59 billion m³of water withdrawal respectively in 2010, of which 848.06 and 973.91 million m³was consumed. Among all energy products, electricity contributed the largest share to the energy sector's water footprint in both regions.
, Journal of Building Engineering, Volume 18, July 2018
The European Union implemented Ecodesign and Labelling Directives to support the market diffusion of energy efficient products. Accurate signals for consumers on energy efficiency (EE) are essential, as disinformation might lead to sub-optimal market allocations. Considering complex devices such as heat pumps (HPs), a conflict between simplicity of calculation on the one hand and accuracy on the other hand arises.
, Resources, Conservation and Recycling, Volume 133, June 2018
Sustainable use and management of nutrients is an important issue for food, energy and water systems. The close connections between the three systems, reflected by the “nexus” concept, warrant an integrated approach to nutrients management across the nexus. In this paper, dynamic modelling of nutrient flows in a local food-energy-water system is presented and applied to a simplified case study.
, The Lancet Global Health, Volume 5, September 2017
Background The ambitious development agenda of the Sustainable Development Goals (SDGs) requires substantial investments across several sectors, including for SDG 3 (healthy lives and wellbeing). No estimates of the additional resources needed to strengthen comprehensive health service delivery towards the attainment of SDG 3 and universal health coverage in low-income and middle-income countries have been published. Methods We developed a framework for health systems strengthening, within which population-level and individual-level health service coverage is gradually scaled up over time.
, Social Science and Medicine, Volume 151, February 01, 2016
Rationale: Food insecurity has emerged as an important, and potentially modifiable, risk factor for depression. Few studies have brought longitudinal data to bear on investigating this association in sub-Saharan Africa. Objective: To estimate the association between food insufficiency and depression symptom severity, and to determine the extent to which any observed associations were modified by social support.
, Environmental Modelling and Software, Volume 62, December 01, 2014
Agricultural systems models worldwide are increasingly being used to explore options and solutions for the food security, climate change adaptation and mitigation and carbon trading problem domains. APSIM (Agricultural Production Systems sIMulator) is one such model that continues to be applied and adapted to this challenging research agenda.
, Journal of the American College of Radiology, Volume 9, July 2012
The 2011 RAD-AID Conference on International Radiology for Developing Countries discussed data, experiences, and models pertaining to radiology in the developing world, where widespread shortages of imaging services significantly reduce health care quality and increase health care disparities. This white paper from the 2011 RAD-AID conference represents consensus advocacy of multidisciplinary strategies to improve the planning, accessibility, and quality of imaging services in the developing world.