Steroidal alkaloids from bioactive sources as a potential therapeutic approach to managing Alzheimer’s. It is a review, but I think it shines a really unique light in underexplored, and oft inexpensive, approaches.
The study demonstrates that the peptide PHDP5, which inhibits dynamin-MT interaction, can rescue impaired endocytosis and synaptic transmission caused by tau in presynaptic terminals. When administered intranasally to Alzheimer's disease (AD) model mice, PHDP5 significantly improved learning and memory, suggesting its potential as a candidate for human AD therapy.
Despite significant investment, effective treatments for Alzheimer's disease (AD) have been elusive, necessitating improved quality and reproducibility of foundational laboratory evidence; to address this, AD-SOLES, an integrated workflow of automated tools and a publicly accessible interactive dashboard, has been developed to collect, curate, and visualize in vivo experimental evidence, enhancing evidence synthesis, tracking reporting quality, and aiding researchers in locating relevant data.
Nurse practitioners and other health care providers can play a crucial role in implementing chronic disease management strategies and educating patients who are at risk for AD among African Americans and Hispanics.
The study investigates the neuroprotective effects of hordenine against AlCl3-induced Alzheimer’s disease in rats. Results show that hordenine improves memory and cognitive functions, suggesting its potential to reverse oxidative stress and neuroinflammation associated with Alzheimer’s
More than 1100 people came together virtually on 18 June 2024 for the tenth edition of the RELX SDG Inspiration Day: "In the Age of AI: Information to Advance the UN Sustainable Development Goals (SDGs)." The annual online event brings together thought leaders, corporate representatives, students, investors, governments, and NGOs to explore pressing issues, gain practical insight, and inspire action on the United Nations Sustainable Development Goals (SDGs).
This study reveals that the estimation of lipids and carotenoid levels could support the early diagnosis or help to understand the pathophysiology of Alzheimer's Disease.
This paper highlights the importance for conservation biologists and on-the-ground practitioners to engage more with local pastoralists to tackle the complex and infrequently described conflicts on how best to implement protective policies.
Recognising our customers' exceptional work to achieve the UN Sustainable Development Goals.
Olfactory impairments are notably present in MCI, particularly with significant declines in odor identification, similar to the primary sensory deficit observed in AD, suggesting the incorporation of odor identification tests for early AD detection.
