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This study developed a novel mouse model with tamoxifen-inducible knockout of the Gnpat gene, enabling late-onset plasmalogen deficiency to investigate its role in Alzheimer's disease. The model exhibited significant plasmalogen reduction and associated behavioral and nerve function changes, providing a valuable tool for future research on plasmalogen involvement in neurodegeneration and potential therapies.
This review explores using nanotechnology to enhance the delivery of neuroprotective phytochemicals from medicinal plants for Alzheimer's disease (AD), addressing issues of bioavailability, solubility, and blood-brain barrier penetration, and highlights the potential of nanocarriers to revolutionize neuroprotective drug delivery and improve patient outcomes.
The study explores the use of a novel gene delivery system, AAV-aMTD-Parkin, to enhance motor and cognitive functions in animal models of Parkinson’s and Alzheimer’s diseases. This system improves the delivery efficiency of therapeutic proteins, potentially offering a new treatment approach for these neurodegenerative disorders.
This study found that female 5XFAD mice exhibit early impairments in prefrontal-dependent cognitive functions and increased activity of prefrontal PV neurons, unlike their male counterparts. These findings suggest a potential mechanism for the higher risk of Alzheimer's disease in women, highlighting sex-specific early deregulation in the prefrontal cortex.

This chapter aligns with several SDG goals. Goal 3: Good Health and Well-Being: the chapter discusses the poor health status and health disparities faced by Indigenous populations globally (higher rates of infant mortality, maternal mortality, malnutrition etc.) and advocates for targeted policy responses and improved access to healthcare services. Goal 10: the chapter discusses the social, economic, and political marginalization of Indigenous peoples worldwide, describing how Indigenous communities are often denied self-determination, face ongoing loss of land and resources, and experience systemic discrimination. Goal 15: Life on Land: the chapter discusses the close relationship between the health of Indigenous peoples and the health of their traditional lands and ecosystems. It highlights the importance of biodiversity conservation and the need to recognize the rights of Indigenous communities to their ancestral territories and natural resources.

Elsevier,

Water Treatment Using Engineered Carbon Nanotubes, Micro and Nano Technologies series, 2024, Pages 63-96

Aligns with Goals 12 and 13 by describing the role of carbon-based materials in water treatment, the challenges to progress, and the future of these carbon-based materials in this field.
The study investigates the neuroprotective effects of hordenine against AlCl3-induced Alzheimer’s disease in rats. Results show that hordenine improves memory and cognitive functions, suggesting its potential to reverse oxidative stress and neuroinflammation associated with Alzheimer’s
The study demonstrates that the peptide PHDP5, which inhibits dynamin-MT interaction, can rescue impaired endocytosis and synaptic transmission caused by tau in presynaptic terminals. When administered intranasally to Alzheimer's disease (AD) model mice, PHDP5 significantly improved learning and memory, suggesting its potential as a candidate for human AD therapy.
Despite significant investment, effective treatments for Alzheimer's disease (AD) have been elusive, necessitating improved quality and reproducibility of foundational laboratory evidence; to address this, AD-SOLES, an integrated workflow of automated tools and a publicly accessible interactive dashboard, has been developed to collect, curate, and visualize in vivo experimental evidence, enhancing evidence synthesis, tracking reporting quality, and aiding researchers in locating relevant data.

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