Indigenous Peoples face disproportionate risks from climate change while being key to planetary health and climate resilience due to their traditional ecological knowledge. This manuscript provides Indigenous perspectives on climate justice, exploring the intersection of health, sovereignty, and ancestral practices, and discusses opportunities for decolonizing relationships to place, highlighting a case of rematriation and healing at Bdóte, the place of genesis for Dakota Peoples, also known as Minneapolis and Saint Paul, MN.
The results of this study emphasize the importance of considering lifestyle aspects like sleep, physical activity, and social support when creating effective strategies to prevent depression in university students.
International Youth Day 2025
International Youth Day (IYD) is dedicated to drawing attention to the cultural and legal issues surrounding youth. Established by the United Nations in 1999, this day serves as a platform for governments and organizations to address the challenges faced by young people and to recognize their contributions to global development. Observed annually on August 12th, IYD encourages activities that promote awareness, dialogue, and action on youth-related issues.
The Significance of Youth
This review provides a comprehensive overview of both conventional and novel therapeutic strategies for Alzheimer's disease (AD), highlighting traditional Acetylcholinesterase (AChE) inhibition and emerging approaches such as Butyrylcholinesterase (BChE) inhibition, Tau Protein inhibitors, and COX-2 inhibition, while also exploring the roles of endocannabinoids, cholesterol-lowering drugs, and microRNA, alongside novel research tools and current clinical trials, to offer a consolidated resource for advancing AD treatment and research.
This study aimed to examine relationships among eating frequency, timing and time window, and cognitive performance and novel Alzheimer disease (AD) biomarkers in cognitively healthy and mildly cognitively impaired middle-aged and older adults. It concluded that an eating pattern characterized by less frequent eating and/or by earlier times is present in individuals with worse cognitive performance. The results shed light on the relevance of temporal eating patterns as potential early markers of behavioral or metabolic changes related to AD pathology.
Every year, 10 million people develop dementia, most commonly Alzheimer's disease (AD), and despite limited therapies and no prevention for cognitive decline, this review offers a neuroimmunological perspective on AD progression, focusing on the role of the NLRP3 inflammasome, its brain triggers, and the potential impact of various NLRP3 inhibitors currently under investigation in preclinical and clinical trials.
With evident relevance to SDG 6, the research explores a water pollution control technology evaluation model based on the Pythagorean language neutrosophic set (PLNS) in the context of the pulp and paper industry. The authors' model aims to assist in the choice of appropriate water pollution control technology for those working within the paper industry. It is tested in an example based in China.
This article discusses the impact of methionine oxidation on clusterin function in Alzheimer's disease, highlighting the elevated levels of MetO-clusterin in human and mouse brains affected by the disease, and how this oxidation compromises clusterin's chaperone function, potentially exacerbating beta-amyloid toxicity in Alzheimer's pathology.
This study found that Alzheimer’s disease neuropathological change (ADNC) is associated with gene expression changes that may impair cholesterol biosynthesis in neurones but not astrocytes, whilst levels of cortical cholesterol show a weak relationship to dementia status.
