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This study developed a novel mouse model with tamoxifen-inducible knockout of the Gnpat gene, enabling late-onset plasmalogen deficiency to investigate its role in Alzheimer's disease. The model exhibited significant plasmalogen reduction and associated behavioral and nerve function changes, providing a valuable tool for future research on plasmalogen involvement in neurodegeneration and potential therapies.

This study found that female 5XFAD mice exhibit early impairments in prefrontal-dependent cognitive functions and increased activity of prefrontal PV neurons, unlike their male counterparts. These findings suggest a potential mechanism for the higher risk of Alzheimer's disease in women, highlighting sex-specific early deregulation in the prefrontal cortex.

This review investigates the connection between Type 2 Diabetes Mellitus and Alzheimer's disease, focusing on common mechanisms and the potential of traditional Indian herbs to manage both conditions. It also addresses the challenges and innovative strategies in delivering herbal formulations.

This chapter aligns with several SDG goals. Goal 3: Good Health and Well-Being: the chapter discusses the poor health status and health disparities faced by Indigenous populations globally (higher rates of infant mortality, maternal mortality, malnutrition etc.) and advocates for targeted policy responses and improved access to healthcare services. Goal 10: the chapter discusses the social, economic, and political marginalization of Indigenous peoples worldwide, describing how Indigenous communities are often denied self-determination, face ongoing loss of land and resources, and experience systemic discrimination. Goal 15: Life on Land: the chapter discusses the close relationship between the health of Indigenous peoples and the health of their traditional lands and ecosystems. It highlights the importance of biodiversity conservation and the need to recognize the rights of Indigenous communities to their ancestral territories and natural resources.