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This study reveals that Dl-3-n-butylphthalide (NBP) improves learning deficits and reduces Aβ plaque deposition in Alzheimer's disease (AD) transgenic mice by enhancing microglial activation and phagocytosis of Aβ plaques. The therapeutic effects of NBP are linked to the AGE-RAGE signaling pathway, demonstrating its potential in alleviating cognitive impairment and neuroinflammation in AD.
This study identified key biochemical pathways and protein changes in the Alzheimer's disease (AD) human hippocampus, revealing increased expression of proteins VGF, GFAP, HSPB1, and APP, with UBC being most centrally involved, and highlighted the roles of four hub proteins (CD44, APP, ITGB2, APOE) linked to amyloid plaques and two (RPL24, RPS23) to neurofibrillary tangles, along with the impact of modified proteins on immune activation and synaptic disruption, uncovering potential therapeutic targets involving specific proteins, microRNAs, and transcription factors.
This Article supports SDG3 by evaluating sex and gender disparities in terms of risk factors, treatment uptake/completion, and virological outcomes for hepatitis C, finding differences between men and women in, for example, exposure to different risk factors and likelihood of commencing treatment. More attention is needed in research to these disparities and how they could be addressed
This research emphasizes the importance of equitable governance and recognizing the leadership roles of Indigenous peoples and local communities in conservation efforts. The study suggests that more positive ecological outcomes are associated with governance structures that give Indigenous peoples and local communities equal partnership or primary control, aligning with the goals of the International Day of Indigenous Peoples to elevate their leadership roles and respect their rights and customary institutions in conservation initiatives.

World Environment Day on June 5 is the biggest international day for the environment. Countries across the globe participate in this UN international day, with millions of people in government, business, civil society, schools and celebrities engaging online and in-person to raise awareness and influence environmental action. World Environment Day in 2024 focuses on restoring land, building drought resilience and stopping desertification under the campaign slogan, “Our Land.

This content aligns with Goal 3: Good Health provides understanding the mechanisms involved in AIH pathogenesis controlling hepatitic inflammation.

This chapter advances the UN SDG goals 9 and 11 by exploring the potential of AI tools to promote sustainable transportation in electric vehicles.
We’re passionate about helping students learn more about STEM, and through our academic program we give students the opportunity to collaborate on STEM-related projects involving innovative technologies like data analytics, robotics and AI. Since 2011, we have partnered with a number of universities to sponsor research projects, internships, robotics teams, scholarships, and other educational programs that provide students with access to hands-on learning and real-world engineering experience.

The study introduces a nano-modulator that targets the damaged blood-brain barrier in Alzheimer’s disease. This modulator releases therapeutic agents that reduce amyloid-beta load, alleviate neuroinflammation, and restore neurovascular unit function, showing potential for Alzheimer’s treatment.

The International Day for Biodiversity (IDB) is celebrated every year on 22 May to raise awareness of the importance and value of biodiversity and to increase understanding of biodiversity issues. The theme of IDB 2024, “Be part of the Plan”, is a call to action for all stakeholders to halt and reverse the loss of biodiversity by supporting the implementation of the Kunming-Montreal Global Biodiversity Framework, or the “The Biodiversity Plan”. To mark International Day for Biodiversity, Elsevier has curated a special collection of journal articles and book chapters exploring .

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