Background: The effect of long-term exposure to air pollution on the development of chronic obstructive pulmonary disease (COPD) is still controversial, and the role of the interactions of air pollution with genetic risk and lifestyle in COPD risk is unclear. Methods: We included 452762 participants derived from the UK Biobank. Annual concentrations of air pollutions, including particle matter (PM2.5, PM10), nitrogen oxides (NOx), and nitrogen dioxide (NO2), were assessed using land-use regression model.
Background: A considerable proportion of people who inject drugs are unstably housed. Although unstable housing is associated with HIV and HCV infection among people who inject drugs, its contribution to transmission is unknown. We estimated the global and national proportions of incident HIV and HCV infections among people who inject drugs attributed to housing instability from 2020 to 2029.
Research suggests that racial/ethnic disparities in COVID-19 in the US are largely driven by higher rates of exposure to SARS-CoV-2 among Hispanic/Latino and Black populations. Occupational exposures play a large role in structuring risk of exposure, and essential workers are at elevated risk of COVID-19 infection. At a national-level, workers categorized as “essential” and “high-risk” are disproportionately Hispanic/Latino, but we lack analysis examining local-level racial/ethnic disparities in potential occupational exposures.
A Viewpoint on Europe's response to climate change, in the context of SDGs 12, 13, and 17, focusing specifically on the use of region-specific indicators to address the main challenges and opportunities of Europe's response in the context of public and planetary health.
Background: Nearly 40% of the world's population is exposed daily to household air pollution. The relative impact of prenatal and postnatal household air pollution exposure on early childhood pneumonia, a leading cause of mortality, is unknown. Research Question: Are prenatal or postnatal household air pollution, or both, associated with pneumonia risk in the first year of life? Study Design and Methods: The Ghana Randomized Air Pollution and Health Study enrolled 1,414 nonsmoking, pregnant women before 24 weeks’ gestation with prospective follow-up to the child's age of 1 year.
We explore ethical premises and practical implications of using genetic testing to predict suicide risk. Twin studies indicate heritable components of suicide risk, intertwined with the heritability of mental disorders, and possibly other traits. Current genetics research has abandoned searching for single gene Mendelian determinants, in favour of complex probabilistic epigenetic models. Genome-Wide Association Studies (GWAS) might identify thousands of single nucleotide polymorphisms (SNPs), each contributing very little to the variance associated with behavioral phenotypes.
Concentrations of nine heavy metal (loid)s (HMs) were determined in fourteen different small indigenous species (SIS) of freshwater fish using atomic absorption spectrophotometer (AAS) technique. Mean concentrations of HMs in the investigated SIS of fish samples ranged from (0.284–1.554), (0.002–0.035), (0.055–0.431), (0.005–0.018), (0.011–0.252), (0.216–23.948), (0.460–34.616), (0.529–3.281), and (4.473–50.560) mg/kg-fw for Pb, Cd, Cr, As, Hg, Mn, Fe, Cu, and Zn, respectively. Statistically significant difference (p
Background: Associations between high and low temperatures and increases in mortality and morbidity have been previously reported, yet no comprehensive assessment of disease burden has been done. Therefore, we aimed to estimate the global and regional burden due to non-optimal temperature exposure. Methods: In part 1 of this study, we linked deaths to daily temperature estimates from the ERA5 reanalysis dataset.
Background: Criteria for low-dose CT scan lung cancer screening vary across guidelines. Knowledge of the eligible pool across demographic groups can enable policy and programmatic decision-making, particularly for disproportionately affected populations. Research Question: What are the eligibility rates for low-dose CT scan screening according to sex and race or ethnicity and how do these rates relate to corresponding lung cancer incidence rates?
The Warsaw International Mechanism for Loss and Damage has identified increasing temperatures as a key slow onset event. However, it is the resulting increases in short-term heat events — heatwaves — that have so far been the primary focus of risk assessment and policy, while gradual and sustained increases in temperature have received less attention. This is a global issue but particularly important in tropical and subtropical regions already chronically exposed to extreme heat.
