Structure Activity Relation

Elsevier, International Journal of Intercultural Relations, Volume 85, November 2021
This article examines the role of empathy for outgroup helping, collective action and political activism among youth in Northern Ireland, a setting of protracted conflict. Integrating the Empathy-Attitudes-Action model with the Developmental Peacebuilding Model, a two-wave study was conducted to assess youth's behavioural intentions and actual behaviours toward refugees.
Chagas disease, Human African Trypanosomiasis, and schistosomiasis are neglected parasitic diseases for which new treatments are urgently needed. To identify new chemical leads, we screened the 400 compounds of the Open Access Malaria Box against the cysteine proteases, cruzain (Trypanosoma cruzi), rhodesain (Trypanosoma brucei) and SmCB1 (Schistosoma mansoni), which are therapeutic targets for these diseases. Whereas just three hits were observed for SmCB1, 70 compounds inhibited cruzain or rhodesain by at least 50% at 5 μM.