In a world where the demand for energy continues to rise and fossil-fuel reserves become more depleted each day, we desperately need new clean energy resources to keep pace with the demand. Renewable energy generated via wind, solar, geothermal, and tidal power will help to reduce our CO2 emissions by 80% of 1990 levels by 2050, but implementing these resources is challenging. In this Catalysis piece, Kaltsoyannis and Liddle explore the role that nuclear power will play in the future. In particular, they discuss the major problems associated with nuclear power and how chemists and fundamental chemical research can take a lead role in providing solutions to make it clean and support SDG 7. This catalyst article generates two reaction responses from Dame Sue Ion and Dr. Robin Taylor.