, Frontiers in Neuroendocrinology, Volume 60, January 2021
Women represent ⅔ of the cases of Alzheimer's disease (AD). Current research has focused on differential risks to explain higher rates of AD in women. However, factors that reduce risk for AD, like cognitive/brain reserve, are less well explored. We asked: what is known about sex and gender differences in how reserve mitigates risk for AD?
, Mechanisms of Ageing and Development, Volume 190, September 2020
Diagnosis of Alzheimer's disease (AD) is often difficult because of distinct and subjective clinical features, especially in the early stage. FOXO3a protein present in the cognitive centre of brain in inferior temporal region and parahippocampus. FOXO3a can be a potential novel target against AD. AD, Mild Cognitive impairment (MCI) and Geriatric Control (GC) were recruited after diagnosis by clinical assessment, MRI, TauPET and FDG-PET. We have quantified serum FOXO3a by surface plasmon resonance (SPR) and compare with TauPET between of AD, MCI patients and GC.
, Biomedical Signal Processing and Control, Volume 62, September 2020
Objective imaging-based biomarker discovery for psychiatric conditions is critical for accurate diagnosis and treatment. Using a machine learning framework, this work investigated the utility of brain's functional network topology (complex network features) extracted from functional magnetic resonance imaging (fMRI) functional connectivity (FC) as viable biomarker of autism spectrum disorder (ASD). To this end, we utilized resting-state fMRI data from the publicly available ABIDE dataset consisting of 432 ASD patients and 556 matched healthy controls.