Unclassified Drug

Background & aims: Recent experimental models and epidemiological studies suggest that specific environmental contaminants (ECs) contribute to the initiation and pathology of non-alcoholic fatty liver disease (NAFLD). However, the underlying mechanisms linking EC exposure with NAFLD remain poorly understood and there is no data on their impact on the human liver metabolome. Herein, we hypothesized that exposure to ECs, particularly perfluorinated alkyl substances (PFAS), impacts liver metabolism, specifically bile acid metabolism.
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Oxidation of engineered nanomaterials during application in various industrial sectors can alter their toxicity. Oxidized nanomaterials also have widespread industrial and biomedical applications. In this study, we evaluated the cardiopulmonary hazard posed by these nanomaterials using oxidized carbon black (CB) nanoparticles (CBox) as a model particle. Particle surface chemistry was characterized by X-ray photo electron spectroscopy (XPS) and Fourier-transform infrared spectroscopy (FTIR).
Objective: Information about the adverse effects of the COVID-19 pandemic on adolescent and adult mental health is growing, yet the impacts on preschool children are only emerging. Importantly, environmental factors that augment or protect from the multidimensional and stressful influences of the pandemic on emotional development of young children are poorly understood. Methods: Depressive symptoms in 169 preschool children (mean age 4.1 years) were assessed with the Preschool Feelings Checklist during a state-wide stay-at-home order in Southern California.
Elsevier, Clinics in Chest Medicine, Volume 42, March 2021
Pulmonary arterial hypertension (PAH) occurs in women more than men whereas survival in men is worse than in women. In recent years, much research has been carried out to understand these sex differences in PAH. This article discusses clinical and preclinical studies that have investigated the influences of sex, serotonin, obesity, estrogen, estrogen synthesis, and estrogen metabolism on bone morphogenetic protein receptor type II signaling, the pulmonary circulation and right ventricle in both heritable and idiopathic pulmonary hypertension.
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Environmental risk factors, including physicochemical agents, noise and mental stress, have a considerable impact on human health. This environmental exposure may lead to epigenetic reprogramming, including changes in non-coding RNAs (ncRNAs) signatures, which can contribute to the pathophysiology state. Oxidative stress is one of the results of this environmental disturbance by modifying cellular processes such as apoptosis, signal transduction cascades, and DNA repair mechanisms.
Glucose-dependent Insulinotropic polypeptide (GIP) is a peptide hormone of the incretin family. It has growth factor properties and can re-activate energy utilization. In progressive neurodegenerative disorders such as Alzheimer's and Parkinson's disease, energy utilization is much reduced, and GIP has the potential to reverse this. Furthermore, GIP can reduce the inflammation response in the brain and reduce levels of pro-inflammatory cytokines. Tests in animal models of Alzheimer's and Parkinson's disease show good neuroprotective effects.
Soil contamination by potentially toxic elements (PTEs) has led to adverse environmental impacts. In this review, we discussed remediation of PTEs contaminated soils through immobilization techniques using different soil amendments with respect to type of element, soil, and amendment, immobilization efficiency, underlying mechanisms, and field applicability. Soil amendments such as manure, compost, biochar, clay minerals, phosphate compounds, coal fly ash, and liming materials are widely used as immobilizing agents for PTEs.
Mercury contamination in soil, water and air is associated with potential toxicity to humans and ecosystems. Industrial activities such as coal combustion have led to increased mercury (Hg) concentrations in different environmental media. This review critically evaluates recent developments in technological approaches for the remediation of Hg contaminated soil, water and air, with a focus on emerging materials and innovative technologies. Extensive research on various nanomaterials, such as carbon nanotubes (CNTs), nanosheets and magnetic nanocomposites, for mercury removal are investigated.
The two-dimensional (2D) ultrathin Mg-Al layered double hydroxide modified by magnetic Fe3O4 (Fe3O4/Mg-Al LDH) was successfully synthesized via the co-precipitation method. The Fe3O4/Mg-Al LDH not only exhibits superior separation efficiency of charge carriers but also possesses signally enhanced photocatalytic activity for CO2 reduction than Mg-Al LDH. The as-prepared Fe3O4/Mg-Al LDH affords the CO and CH4 generation rate of 442.2 µmol g−1 h−1 and 223.9 µmol g−1 h−1. The enhanced reduction CO2 activity mainly comes from synergetic effect of Fe3O4 and ultrathin Mg-Al LDH.
Chagas disease, Human African Trypanosomiasis, and schistosomiasis are neglected parasitic diseases for which new treatments are urgently needed. To identify new chemical leads, we screened the 400 compounds of the Open Access Malaria Box against the cysteine proteases, cruzain (Trypanosoma cruzi), rhodesain (Trypanosoma brucei) and SmCB1 (Schistosoma mansoni), which are therapeutic targets for these diseases. Whereas just three hits were observed for SmCB1, 70 compounds inhibited cruzain or rhodesain by at least 50% at 5 μM.

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