Managing Treatment-Resistant Depression - Chapter 2 Clinical and epidemiological predictors of treatment-resistant depression

Clinicians and researchers have tried for decades to identify possible predictors of response to antidepressants, to possibly stratify risk, improve outcomes, and ultimately to personalize the choice of antidepressant treatment. This chapter will review the data on clinical and epidemiological predictors of antidepressant response, or predictors of treatment-resistant depression. We will discuss the possible prognostic value of clinical features, like severity, chronicity, subtypes of depression, comorbidities, history of trauma, and epidemiological features like gender, age, sociodemographic status.