In vivo triple transgenic AD mouse model brains and retinas showed hypoxic vessels expressing hypoxyprobe and HIF-1α. In in vitro OGD-treated endothelial cells, HIF-1α upregulated NADPH oxidase (NOX) (i.e., Nox2, Nox4). NLRP1 protein was promoted by OGD, and such effect was blocked by downregulation of Nox4 and HIF-1α. Hypoxic endothelial cells of AD brains and retinas markedly expressed NLRP1, ASC, caspase-1, and interleukin-1β (IL-1β). Chronic hypoxia in microvascular endothelial cells leads to HIF-1α-NLRP1 circuit in AD.
This study observes that oxidative dame in Alzheimer's Diseases is a pathogenic mechanism at the cell-tissue level.
PHQ-8 could be used for screening and severity assesment of depressive symptoms at the European level.
This Health Policy paper supports SDGs 2, 3, and 13, by identifying and examining the debates that arose from the publication of the EAT–Lancet Commission, systematically examining how research has been directly influenced by the Commission, and synthesising identified research gaps to build a research agenda for healthy and sustainable food systems.
Background: Over the past three decades, the prevalence of adolescent emotional problems (ie, anxiety and depression) has risen.
Background: Few studies have evaluated postnatal depression before and during the Covid-19 pandemic using comparable data across time.
Background: The role of alcohol use in the development of depression is unclear.
The authors of this paper conclude that reducing Ultraprocessed Drink Consumption could lower environmental impact and all-cause mortality risk; however, this was not shown for Ultraprocessed Foods. When categorizing food consumption by their degree of processing, trade-offs are observed for human and planetary health aspects.
Climate change is impacting the health of Western Australians.Temperature increases and air pollution are particularly problematic.Food and water security may be compromised. An urgent response is required.
