Despite global progress, maternal mortality remains high, especially in sub-Saharan Africa, highlighting the urgent need for strong leadership, increased investment in well-trained midwives, and equitable, culturally sensitive maternity care to achieve the Sustainable Development Goal of reducing maternal deaths to less than 70 per 100,000 live births by 2030.
This study identified over 2,000 proteins in cerebrospinal fluid that change at different stages before Alzheimer's symptoms appear, revealing key biological processes involved in the disease. Using machine learning, the researchers developed highly accurate models to predict Alzheimer's biomarker status, clinical diagnosis, and future disease progression.
hLife
Volume 3, Issue 5
2025
2025
This review article explores advancements in 3D models using human iPSC-derived microglia to study neurodevelopment and neurological disorders, highlighting the potential of these models to enhance understanding of microglial functions and their roles in various diseases. The article also discusses the challenges and future directions in developing more physiologically relevant brain organoid models.
The "Multigenerational Resilience Theory" highlights the cultural and intergenerational nature of resilience in indigenous communities, offering new strategies for addressing modern challenges.
This article outlines a theory of goodness, coupled with some of its practical implications for impact-making, governance and lives more generally. The theory proposes that goodness consists of positive feelings and whatever promotes them, such as the joy of a meaningful conversation or the satisfaction of eating food, for instance. Although it is a version of ethical hedonism, the theory is also called welfarism since it allocates a central role to affect and since affect is central to some prevalent measures of 'subjective wellbeing'.
Drivers of health disparities in rheumatology are numerous and complex, existing within and between populations. These impact access to advanced therapies, specialized services, and core components of care.
