Health and wellbeing

Health and well-being have a central role in the 17 Sustainable Development Goals (SDGs) endorsed by the United Nations, emphasizing the integral part they play in building a sustainable future. The third SDG explicitly calls for ensuring healthy lives and promoting well-being for all at all ages. This goal encompasses a wide range of health objectives, from reducing maternal and child mortality rates, combatting disease epidemics, to improving mental health and well-being. But beyond SDG 3, health is intrinsically linked with almost all the other goals.

When addressing SDG 1, which aims to end poverty, one cannot neglect the social determinants of health. Economic hardship often translates into poor nutrition, inadequate housing, and limited access to health care, leading to a vicious cycle of poverty and poor health. Similarly, achieving SDG 2, ending hunger, also contributes to better health through adequate nutrition, essential for physical and mental development and the prevention of various diseases.

Conversely, the repercussions of climate change, encapsulated in SDG 13, profoundly impact health. Rising global temperatures can lead to increased spread of infectious diseases, compromised food and water supplies, and increased frequency and intensity of extreme weather events, all posing severe health risks. Conversely, the promotion of good health can also mitigate climate change through the reduction of carbon-intensive lifestyles and adoption of healthier, more sustainable behaviors.

SDG 5, advocating for gender equality, also has substantial health implications. Ensuring women's access to sexual and reproductive health services not only improves their health outcomes, but also contributes to societal and economic development. Furthermore, achieving SDG 4, quality education, is also critical for health promotion. Education fosters health literacy, empowering individuals to make informed health decisions, hence improving overall community health.

Lastly, SDG 17 underlines the importance of partnerships for achieving these goals. Multi-sector collaboration is vital to integrate health considerations into all policies and practices. Stakeholders from various sectors, including health, education, agriculture, finance, and urban planning, need to align their efforts in creating sustainable environments that foster health and well-being.

Hence, the relationship between health, well-being, and the SDGs is reciprocal. Improving health and well-being helps in achieving sustainable development, and vice versa. In this context, health and well-being are not just outcomes but are also powerful enablers of sustainable development. For the world to truly thrive, it must recognize and act upon these interconnections.

This article provides a bibliometric analysis of 545 linguistics research articles on dementia published between 1994 and 2023, highlighting key contributors, influential journals, and foundational references.
This study presents AlzFormer, a novel deep learning framework utilizing spatiotemporal self-attention to classify Alzheimer’s disease (AD), mild cognitive impairment (MCI), and cognitively normal (CN) individuals from structural MRI scans. By modeling MRI volumes as sequential slice-based inputs and fine-tuning a pre-trained TimeSformer model, AlzFormer achieved 94% accuracy and high class-wise F1-scores, while attention map analyses highlighted clinically relevant brain regions, demonstrating both robust performance and interpretability in multiclass AD diagnosis.
This article provides a comprehensive review of the use of graphene-based biosensing platforms for the early detection of Alzheimer's disease. It is found that graphene-based biosensors can detect Alzheimer's disease biomarkers at femtomolar concentrations, enabling early diagnosis before symptom onset. These sensors can also identify multiple biomarkers simultaneously in accessible biofluids like blood, saliva, and urine, enabling less invasive testing.
Report on a new smart delivery system designed to target and treat Alzheimer's disease more effectively, aiming to overcome the challenges of current treatments and offering a promising way to fight Alzheimer's more accurately and safely.
Elsevier,

Brain Network Disorders, Volume 1, Issue 3, September 2025, Pages 150-166

The article discusses the potential of neuron-derived extracellular vesicles (NDEVs) as diagnostic biomarkers for Alzheimer's disease (AD). NDEVs carry pathological proteins like amyloid-? and Tau, and their levels in bodily fluids can distinguish AD patients from healthy controls and predict disease onset.

Elsevier,

Journal of the Society for Cardiovascular Angiography and Interventions, Volume 4, September 2025

The 30-day Society of Thoracic Surgeons Predicted Risk of Mortality (STS-PROM) has been used to risk-stratify patients undergoing transcatheter aortic valve replacement (TAVR). Whether surgical mortality risk predicts stroke and neurocognitive outcomes following TAVR is unknown. We evaluated the association between STS-PROM and clinical outcomes, including stroke, acute brain injury on diffusion-weighted magnetic resonance imaging (DW-MRI), and cognitive decline in patients undergoing TAVR.
This study introduces a new, safe, affordable, and non-invasive device designed to detect and monitor early signs of Alzheimer's disease. Unlike traditional tests like MRI or CT scans, this device uses microwaves to examine the brain.
The TRAILBLAZER-ALZ 6 study found that a modified donanemab titration regimen significantly reduced ARIA-E frequency and severity compared to standard dosing, while maintaining similar amyloid reduction. Safety profiles were comparable between the two arms. The modified titration approach may help mitigate risks associated with amyloid-targeting therapies in early Alzheimer's disease.
Elsevier,

Endocrine Practice

Volume 31, Issue 9, Supplement, September 2025, Page S193

 

Evidence from preclinical research suggests that dysfunction in thyroid hormones may increase ?-amyloid levels and tau phosphorylation, 2 hallmark features of Alzheimer's Disease(AD). This study showed a strong association between hypothyroidism and AD mortality.

The article provides a comprehensive overview of the role of the endogenous detoxification system in the pathogenesis of age-related neurodegenerative diseases, particularly Alzheimer's disease (AD) and Parkinson's disease (PD). It highlights epidemiological evidence linking environmental toxicant exposure to the onset and progression of these diseases, and discusses how dysfunction of detoxification pathways, including enzymes and transporters, can exacerbate neurodegenerative processes. The article also explores the potential of targeting nuclear receptor signaling pathways, such as the pregnane X receptor (PXR), as a promising therapeutic strategy to restore detoxification capacity and modify disease trajectories.

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