Elsevier, The Lancet Global Health, Volume 9, April 2021
Background: The number of individuals with vision impairment worldwide is increasing because of an ageing population. We aimed to systematically identify studies describing the association between vision impairment and mortality, and to assess the association between vision impairment and all-cause mortality. Methods: For this systematic review and meta-analysis, we searched MEDLINE (Ovid), Embase, and Global Health database on Feb 1, 2020, for studies published in English between database inception and Feb 1, 2020. We included prospective and retrospective cohort studies that measured the association between vision impairment and all-cause mortality in people aged 40 years or older who were followed up for 1 year or more. In a protocol amendment, we also included randomised controlled trials that met the same criteria as for cohort studies, in which the association between visual impairment and mortality was independent of the study intervention. Studies that did not report age-adjusted mortality data, or that focused only on populations with specific health conditions were excluded. Two reviewers independently assessed study eligibility, extracted the data, and assessed risk of bias. We graded the overall certainty of the evidence using the Grading of Recommendations, Assessment, Development and Evaluations framework. We did a random-effects meta-analysis to calculate pooled maximally adjusted hazard ratios (HRs) for all-cause mortality for individuals with a visual acuity of
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Article; Best Corrected Visual Acuity; Binge Drinking; Blindness; Cerebrovascular Accident; Comparative Study; Contrast Sensitivity; Diabetes Mellitus; Estimated Glomerular Filtration Rate; Global Health; Human; Humans; International Classification Of Diseases; Intraocular Pressure; Medline; Meta Analysis; Mortality; Outcome Assessment; Randomized Controlled Trial (topic); Randomized Controlled Trials As Topic; Risk Assessment; Risk Factor; Risk Factors; Severity Of Illness Index; Stereoscopic Vision; Systematic Review; Systemic Disease; Vision Disorders; Visual Acuity; Visual Disorder; Visual Field; Visual Impairment; Global