Cognitive dysfunction in schizophrenia: An expert group paper on the current state of the art

Elsevier, Schizophrenia Research: Cognition, Volume 29, September 2022, article 100249
Philip D. Harvey, Marta Bosia, Roberto Cavallaro, Oliver D. Howes, René S. Kahn, Stefan Leucht, Daniel R. Müller, Rafael Penadés, Antonio Vita,

Cognitive impairment in schizophrenia represents one of the main obstacles to clinical and functional recovery. This expert group paper brings together experts in schizophrenia treatment to discuss scientific progress in the domain of cognitive impairment to address cognitive impairments and their consequences in the most effective way. We report on the onset and course of cognitive deficits, linking them to the alterations in brain function and structure in schizophrenia and discussing their role in predicting the transition to psychosis in people at risk. We then address the assessment tools with reference to functioning and social cognition, examining the role of subjective measures and addressing new methods for measuring functional outcomes including technology based approaches. Finally, we briefly review treatment options for cognitive deficits, focusing on cognitive remediation programs, highlighting their effects on brain activity and conclude with the potential benefit of individualized integrated interventions combing cognitive remediation with other approaches.