Elsevier, Cancer Epidemiology, Volume 70, February 2021
Background: The incidence of metastatic spine disease (MSD) is increasing among cancer patients. Given the poor outcomes and high rates of morbidity associated with MSD, it is important to determine demographic factors that could impact interventions and outcomes for this patient population. The objectives of this study were to compare in-hospital mortality and complication rates, clinical presentation, and interventions between female and male patients diagnosed with MSD. Methods: Patient data were collected from the United States National Inpatient Sample (NIS) database from the years 2012−2014. Descriptive statistics were used to compare data from 51,800 cases; subsequently, multivariable logistic regression analyses were conducted to assess the effect of gender on outcomes. Results: Males had significantly higher rates of in-hospital mortality (OR 1.30; 95 % CI 1.09–1.56, p = 0.004) and were more likely to have received surgical intervention than females (OR 1.34; 95 % CI 1.16–1.55, p
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Keywords:
Adolescent; Adult; Aged; Aged, 80 And Over; American Indian; Antineoplastic Agent; Article; Asian; Black Person; Cancer Chemotherapy; Cancer Prognosis; Cancer Radiotherapy; Cancer Surgery; Cancer Therapy; Caucasian; Charlson Comorbidity Index; Clinical Feature; Compression Fracture; Controlled Study; Decubitus; Demography; Disease Course; Female; Gastrointestinal Disease; Gender Disparity; Gender Identity; Groups By Age; Health Insurance; Hispanic; Hospital Mortality; Household Income; Human; Humans; In-hospital Complications; Incidence; Kidney Disease; Major Clinical Study; Male; Metastasis; Metastatic Spine Disease; Middle Aged; Mortality Rate; Mortality Rates; Multivariate Logistic Regression Analysis; Neoplasm Metastasis; Neurological Complication; Pacific Islander; Pathologic Fracture; People By Smoking Status; Pneumonia; Presentation; Primary Tumor; Priority Journal; Prospective Studies; Prospective Study; Respiratory Tract Disease; Retrospective Studies; Retrospective Study; Sepsis; Sex Difference; Spinal Cord Compression; Spinal Diseases; Spine Disease; Spine Metastasis; Spine Tumor; Thromboembolism; Treatment Outcome; Tumor Biopsy; Urinary Tract Infection; Very Elderly; Visceral Metastasis; Young Adult; Global