Elsevier, Drug Discovery Today, Volume 25, May 2020
Beyond their traditional use as green solvents, new applications have become available for ionic liquids (ILs) in drug delivery. Their flexible tunability enables task-specific optimization of ILs at molecular level. Thus, ILs have been exploited to improve the solubility and permeability of drugs and relieve the polymorphic problems associated with crystalline active pharmaceutical ingredients (APIs). Controlled preparation of drug nanocarriers are also achieved by using ILs either as media or as functional agents. Here, we highlight the importance and advantages of ILs in pharmaceutics and look towards the future of IL-based drug delivery.
Animal; Animals; Chemistry; Drug; Drug Carrier; Drug Carriers; Drug Delivery System; Drug Delivery Systems; Drug Effect; Drug Formulation; Drug Penetration; Drug Solubility; Green Chemistry; Human; Humans; Ionic Liquid; Ionic Liquids; Microemulsion; Nanocarrier; Nanoparticle; Nanoparticles; Nonhuman; Permeability; Pharmaceutical Preparations; Procedures; Review; Solubility; Solvent; Solvents; Global