Free Radical Biology and Medicine, Volume 151, 1 May 2020,
Cardiovascular causes have been estimated to be responsible for more than two thirds of the considerable mortality attributed to air pollution. There is now a substantial body of research demonstrating that exposure to air pollution has many detrimental effects throughout the cardiovascular system. Multiple biological mechanisms are responsible, however, oxidative stress is a prominent observation at many levels of the cardiovascular impairment induced by pollutant exposure. This review provides an overview of the evidence that oxidative stress is a key pathway for the different cardiovascular actions of air pollution.
Adverse Event; Air Pollutant; Air Pollutants; Air Pollution; Atherosclerosis; Blood Vessel Tone; Cardiovascular; Cardiovascular Disease; Cardiovascular Diseases; Cardiovascular Effect; Cardiovascular Mortality; Cardiovascular System; Cerebrovascular Accident; Cerebrovascular Disease; Coronary Artery Disease; Diesel Exhaust; Disease Association; Endothelial Dysfunction; Environmental Exposure; Heart Arrest; Heart Arrhythmia; Heart Failure; Heart Infarction; Heart Muscle Ischemia; Heart Rate Variability; Human; Humans; In Vitro Study; Incidence; Nonhuman; Occupational Exposure; Oxidative Stress; Particulate Matter; Peripheral Occlusive Artery Disease; Priority Journal; Review; Thrombosis; Toxicity; Venous Thromboembolism; Global