Principles and Practice of Pediatric Infectious Diseases, 6th Edition - Chapter 213: Hepatitis B and Hepatitis D Viruses

Elsevier, Principles and Practice of Pediatric Infectious Diseases (Sixth Edition), 2023, Pages 1125-1133.e4
Authors: 
Aaron M. Harris, Sarah Schillie

HBV is an enveloped virus with a circular, partially double-stranded DNA genome.

HBV-associated liver damage is caused by the host immune response, not direct cytopathic effects.

HBV is one of the leading causes of infectious disease-related morbidity and mortality worldwide.

HBV is transmitted through percutaneous, sexual, and perinatal routes.

Infants born to HBsAg-positive mothers have a 90% risk of developing chronic HBV infection if infected perinatally.

HDV is an RNA virus that can only infect cells in the presence of HBV and is efficiently transmitted percutaneously.