The activation of the innate immune system and subsequent neuroinflammation are common hallmarks of all neurodegenerative diseases. Castro-Gomez and Heneka review the emerging evidence related to receptors implicated in the activation of innate immunity during neurodegenerative processes. They predominantly focus on the role of microglia, PRRs, and other DAMP-sensing receptors in the pathogenesis of Alzheimer’s disease, tauopathy, Parkinson’s disease, and amyotrophic lateral sclerosis.
The study emphasizes practical application with a user-friendly website, empowering radiologists to predict class probabilities, track disease progression, and visualize patient images in both 2D and 3D formats, contributing significantly to the advancement of early AD detection.
This review explores the role of platelet dysfunction in the pathogenesis of Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA), discussing in vitro, in vivo, and clinical evidence related to platelet activation, adhesion, and aggregation, and highlighting potential therapeutic targets to address amyloid-related AD pathogenesis.
This study demonstrates that electroacupuncture (EA) improves learning and memory in the 5xFAD mouse model of Alzheimer's disease, likely by enhancing functional connectivity between the hippocampus and neocortex and reducing amyloid-β protein expression and deposition. These findings suggest that EA may positively impact resting-state brain activity and connectivity, contributing to cognitive and motor function improvements in AD.
Despite diagnostic challenges in differentiating lvPPA and nfvPPA, particularly in advanced cases, this study reveals divergent clinical courses and highlights the importance of assessing emotion processing capacity in dementia diagnosis and monitoring. Utilizing spatiotemporal LME modelling, the research provides valuable insights into the dynamic changes in brain atrophy and behavior, underscoring the need for ongoing evaluation of clinical requirements for patients and families over the disease course.
This review discusses the multifaceted physiological functions of cholecystokinin (CCK), its potential neuroprotective effects in Alzheimer’s and Parkinson’s diseases, and its therapeutic implications, including its impact on memory, neurotransmitters, and neuroprotection mechanisms.
This article discusses the potential therapeutic strategy of enhancing mitophagy through rapamycin treatment to alleviate cognitive impairment in Alzheimer's disease by improving mitochondrial dysfunction and neuronal loss, suggesting a novel mechanism for the neuroprotective effects of rapamycin in AD.
This study investigated antiviral effects in a real-world cohort of non-cirrhotic CHB patients with varying degrees of HS, assessed by transient elastography (TE) with controlled attenuation parameter (CAP).
The present article reviews the role of necroptosis, as a novel cell death pathway, in Aluminium-induced Alzheimer’s disease models in vitro and in vivo.
This study aims to develop novel prognostic models based on the dynamic changes in variables to predict the short-term mortality of HBV-associated ACLF (HBV-ACL)
