Elsevier, Neuron, Volume 102, 3 April 2019
Here, Nestler and Lüscher link addiction circuits to epigenetic mechanisms that are engaged by drug exposure or reflect life experience. These molecular alterations may not only explain the basis of drug-evoked synaptic plasticity, but may also help understand individual addiction vulnerability.
Category:
Keywords:
Animal; Animals; Biological Variation; Biological Variation, Individual; Brain; Brain Function; Chromatin; Dopamine; Dopaminergic Activity; Drug Dependence; Drug Research; Drug Targeting; Drug Use; Epigenesis, Genetic; Epigenetics; Gene Expression Regulation; Genetic Epigenesis; Genetic Variability; Genetics; Human; Humans; Maladjustment; Metabolism; Molecular Pathology; Nerve Cell Network; Nerve Cell Plasticity; Nerve Tract; Neural Pathways; Neuronal Plasticity; Nonhuman; Pathophysiology; Personal Experience; Priority Journal; Review; Substance-Related Disorders; Synapse; Synapses; Synaptic Transmission; Vulnerable Population; Global
