Neurobiology of Stress, Volume 8, February 2018,
Stress is critically involved in the development and progression of disease. From the stress of undergoing treatments to facing your own mortality, the physiological processes that stress drives have a serious detrimental effect on the ability to heal, cope and maintain a positive quality of life. This is becoming increasingly clear in the case of neurodegenerative diseases. Neurodegenerative diseases involve the devastating loss of cognitive and motor function which is stressful in itself, but can also disrupt neural circuits that mediate stress responses. Disrupting these circuits produces aberrant emotional and aggressive behavior that causes long-term care to be especially difficult. In addition, added stress drives progression of the disease and can exacerbate symptoms. In this review, I describe how neural and endocrine pathways activated by stress interact with ongoing neurodegenerative disease from both a clinical and experimental perspective.
3 (6 Dimethylamino 4 Methyl 3 Pyridinyl) 7 Dipropylamino 2,5 Dimethylpyrazolo[1,5 A]pyrimidine; Aggression; Alzheimer Disease; Alzheimer's Disease; Amyloid Precursor Protein; Anxiety; Anxiolytic Agent; CRF; CRH; Clinical Trial (topic); Cognition; Connectome; Corticosteroid; Corticosteroids; Corticotropin Releasing Factor; Cortisol; Degenerative Disease; Dementia; Depression; Disease Exacerbation; Emotion; Glucocorticoid Receptor Antagonist; Human; Mortality; Motor Performance; Nerve Degeneration; Neurofibrillary Tangle; Nonhuman; Parkinson Disease; Posttraumatic Stress Disorder; Priority Journal; Protein Aggregation; Quality Of Life; R 121919; Review; Stress; Tau Protein; Traumatic Brain Injury; Global