Elsevier, Mechanisms of Ageing and Development, Volume 190, September 2020
Diagnosis of Alzheimer's disease (AD) is often difficult because of distinct and subjective clinical features, especially in the early stage. FOXO3a protein present in the cognitive centre of brain in inferior temporal region and parahippocampus. FOXO3a can be a potential novel target against AD. AD, Mild Cognitive impairment (MCI) and Geriatric Control (GC) were recruited after diagnosis by clinical assessment, MRI, TauPET and FDG-PET. We have quantified serum FOXO3a by surface plasmon resonance (SPR) and compare with TauPET between of AD, MCI patients and GC. Serum FOXO3A was significantly lower in AD (1.42 ± 0.09 ng/μl) compare to MCI (1.61 ± 0.14 ng/μl) and GC (1.89 ± 0.07 ng/μl). However, the Tau was higher in AD both in serum and also in PET scan. Serum pTau was significantly over-expressed in AD (0.176 ± 0.03 ng/μl), compare to other groups; MCI (0.16 ± 0.014 ng/μl) and GC (0.15 ± 0.024 ng/μl). Serum FOXO3A could significantly differentiate AD vs MCI, MCI vs GC and AD vs GC. However, Tau protein could only differentiate AD vs GC but not MCI vs GC. Serum FOXO3A may serve as novel blood marker for early detection for AD and target for therapeutic intervention.
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Keywords:
Adult; Aged; Alzheimer Disease; Article; Biological Marker; Biomarkers; Blood; Case Control Study; Clinical Article; Clinical Assessment; Cognitive Defect; Cognitive Dysfunction; Controlled Study; DNA Methylation; Diagnostic Imaging; Early Diagnosis; FOXO3 Protein, Human; FOXO3A; Female; Forkhead Box Protein O3; Gene Expression Profiling; Geriatric Assessment; Hindi Mental State Examination; Human; Humans; MAPT Protein, Human; Male; Metabolism; Mild Cognitive Impairment; Montreal Cognitive Assessment; P-Tau 181; Parahippocampal Gyrus; Positron Emission Tomography; Positron-Emission Tomography; Priority Journal; Procedures; Protein Blood Level; Protein Expression; SPR; Surface Plasmon Resonance; Tau; Tau Protein; Tau Proteins; TauPET; Temporal Lobe; Transcription Factor FKHRL1; Global