Uncovering the Genetic Architecture of Major Depression

Elsevier, Neuron, Volume 102, 3 April 2019
McIntosh A.M., Sullivan P.F., Lewis C.M.

There have been several recent studies addressing the genetic architecture of depression. This review serves to take stock of what is known now about the genetics of depression, how it has increased our knowledge and understanding of its mechanisms, and how the information and knowledge can be leveraged to improve the care of people affected. We identify four priorities for how the field of MD genetics research may move forward in future years, namely by increasing the sample sizes available for genome-wide association studies (GWASs), greater inclusion of diverse ancestries and low-income countries, the closer integration of psychiatric genetics with electronic medical records, and the development of the neuroscience toolkit for polygenic disorders. A review by McIntosh et al. takes stock of recent rapid progress in the genetics of depression, how it has increased our mechanistic understanding, and how this information could be used to improve patient care in future.