Sex- and gender-based medicine (SGBM) is a new and groundbreaking discipline that has immense potential to improve diagnosis, disease management, and health outcomes. It is grounded in differences in the ways both biological sex and the psychosocial context of gender representation influence disease. Further, SGBM is distinct from women’s health, as it encompasses the health and diseases of both women and men, and it is more than simply sex-specific health issues such as pregnancy, menopause, and cancers confined to either women or men. Rather, SGBM goes to the heart of the practice of holistic, individualized, evidence-based medicine. The majority of organ systems and disease conditions occur in both sexes and fall under the sex- and gender-based health category. People may have a myriad of risk factors that increase their potential for development of disease, and risk profiles vary widely. Sex and gender—two basic human variables—can impact disease occurrence, presentation, diagnosis, response to treatment, and prognosis.
Jenkins et Al. Application of sex and gender health: A practical framework. In: Jenkins et al, How Sex and Gender Impact Clinical Practice, Academic Press, 2021, Pages 3-8.,