The Liver: Chapter 7 - The Role of Glyoxalase-I in Oxidant Stress of Liver Damage

Elsevier, The Liver, Oxidative Stress and Dietary Antioxidants, 2018, Pages 71-78
Marcus Hollenbach and Alexander Zipprich

Glyoxalase-I (Glo-I) is the main detoxifying enzyme for methylglyoxal (MGO) leading to the formation of advanced glycation endproducts (AGEs) and oxidative stress. AGEs bind to their receptor RAGE and activate intracellular transcription factors and inflammation. While data of Glo-I and MGO in liver disease are preliminary, AGEs and RAGE are involved in liver fibrosis and inflammation. AGEs increase α-SMA, collagen deposit, and oxidative stress in inflammatory liver disease.